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Intermittent therapy for the treatment of chronic HIV infection.

机译：间歇疗法用于治疗慢性HIV感染。

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HAART has changed HIV infection from a life-threatening into a chronic condition, but the perspective of never ending HAART once it is started is daunting to many patients. As a cure for HIV infection is currently not in sight, many patients, who are looking to their physicians for advice on whether to stop HAART. New drugs and combinations with better safety and tolerability profiles have become available , but there will still be patients who experience toxicity [1-3]; therefore, being able to take a rest from HAART may be beneficial . Worldwide, the cost of treating millions with HIV burdens fragile economies; intermittent treatment promises relief. Many scheduled treatment interruption (STI) studies have shown between 40 and 60% drug savings with STI [4-7]. For example, in Thailand, using the least expensive generic fixed dose combination of stavudine/lamivudineevirapine, which is USdollar27 per month, the yearly cost of treating 500 000 HIV-positive individuals would decrease from USdollar162 million to .USdollar81 million if there is a 50% drug saving. Moreover, |STI may provide the possibility that a potent and inexpensive drug such as stavudine may still be used widiout many side-effects, whereas continuous use would necessitate its replacement by a less toxic, but mostly more expensive, alternative. However, these potential benefits have to be weighed against the potential risks, which include the development of HIV-related illnesses, acute retroviral syndrome, thrombocytopenia, resistance and the transmission of HIV infection. Antiretroviral drug, HAART, HIV, planned treatment interruption,scheduled treatment interruption
机译：HAART已将艾滋病毒感染从威胁生命的状态转变为慢性病，但是，从一开始就永无止境的HAART的前景使许多患者望而却步。由于目前尚无治疗HIV感染的方法，因此许多患者正在就是否停止HAART向医生寻求建议。具有更好的安全性和耐受性的新药及其组合已经面世，但是仍然会有患者出现毒性反应[1-3]。因此，能够从HAART休息一下可能是有益的。在世界范围内，治疗数百万艾滋病毒的费用使脆弱的经济负担沉重;间歇治疗有望缓解。许多定期治疗中断（STI）研究表明，STI可以节省40％到60％的药物[4-7]。例如，在泰国，如果使用价格最便宜的司他夫定/拉米夫定/奈韦拉平的非专利固定剂量组合药物，即每月27美元，那么，如果有50万艾滋病毒阳性患者，则每年的治疗费用将从1.62亿美元降低至8100万美元。节省了50％的药物。而且，| STI可能会提供一种有效且廉价的药物（例如司他夫定），而不会产生许多副作用，而持续使用将需要用毒性较小但大多昂贵的替代品代替。但是，必须权衡这些潜在的好处与潜在的风险，其中包括与HIV相关的疾病的发展，急性逆转录病毒综合征，血小板减少症，耐药性和HIV感染的传播。抗逆转录病毒药物，HAART，HIV，计划内治疗中断，计划内治疗中断

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