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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Spatial coefficient of variation in pseudo-continuous arterial spin labeling cerebral blood flow images as a hemodynamic measure for cerebrovascular steno-occlusive disease: A comparative O-15 positron emission tomography study
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Spatial coefficient of variation in pseudo-continuous arterial spin labeling cerebral blood flow images as a hemodynamic measure for cerebrovascular steno-occlusive disease: A comparative O-15 positron emission tomography study

机译：伪连续动脉旋转标记脑血流图像的空间变异系数作为脑血管闭塞性疾病的血流动力学措施：比较O-15正电子发射断层扫描研究

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Pseudo-continuous arterial spin labeling (pCASL) is a completely non-invasive method of cerebral perfusion measurement. However, cerebral blood flow (CBF) quantification is hampered by arterial transit artifacts characterized by bright vascular signals surrounded by decreased signals in tissue regions, which commonly appear in patients with reduced cerebral perfusion pressure. The spatial coefficient of variation (CoV) of pCASL CBF images has been proposed as an alternative region-of-interest (ROI)-based hemodynamic measure to predict prolonged arterial transit time (ATT). This retrospective study investigates the utility of spatial CoV by comparison with O-15 positron emission tomography (PET). For patients with cerebrovascular steno-occlusive disease (n = 17), spatial CoV was positively correlated with ATT independently measured by pulsed arterial spin labeling (r = 0.597, p 0.001), confirming its role as an ATT-like hemodynamic measure. Comparisons with O-15 PET demonstrated that spatial CoV was positively correlated with vascular mean transit time (r = 0.587, p 0.001) and negatively correlated with both resting CBF (r = -0.541, p = 0.001) and CBF response to hypercapnia (r = -0.373, p = 0.030). ROI-based spatial CoV calculated from single time-point pCASL can potentially detect subtle perfusion abnormalities in clinical settings.
机译：伪连续动脉旋转标记（PCASL）是一种完全非侵入性的脑灌注测量方法。然而，脑血流（CBF）定量通过动脉转移伪像阻碍，其特征在于由组织区域中的信号降低围绕的明亮血管信号，其通常出现在减少脑灌注压力的患者中。已经提出了PCASL CBF图像的空间变异（COV）作为替代的兴趣区域（ROI）的血液动力学措施，以预测延长的动脉转运时间（ATT）。该回顾性研究通过与O-15正电子发射断层扫描（PET）的比较来研究空间COV的效用。对于脑血管闭塞性疾病（n = 17）的患者，空间COV与通过脉冲动脉旋转标记独立测量的AT呈正相关（R = 0.597，P <0.001），确认其作为att样血液动力学措施的作用。与O-15 PET的比较证明，空间COV与血管平均转动时间呈正相关（r = 0.587，p <0.001），并与静止的CBF（r = -0.541，p = 0.001）和CBF反应对Hypercapnia负相关（r = -0.373，p = 0.030）。基于ROI的空间COV从单位点PCASL计算，可能会在临床环境中检测微妙的灌注异常。

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