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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Basement membrane and stroke
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Basement membrane and stroke

机译：地下室膜和中风

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摘要

Located at the interface of the circulation system and the CNS, the basement membrane (BM) is well positioned to regulate blood-brain barrier (BBB) integrity. Given the important roles of BBB in the development and progression of various neurological disorders, the BM has been hypothesized to contribute to the pathogenesis of these diseases. After stroke, a cerebrovascular disease caused by rupture (hemorrhagic) or occlusion (ischemic) of cerebral blood vessels, the BM undergoes constant remodeling to modulate disease progression. Although an association between BM dissolution and stroke is observed, how each individual BM component changes after stroke and how these components contribute to stroke pathogenesis are mostly unclear. In this review, I first briefly introduce the composition of the BM in the brain. Next, the functions of the BM and its major components in BBB maintenance under homeostatic conditions are summarized. Furthermore, the roles of the BM and its major components in the pathogenesis of hemorrhagic and ischemic stroke are discussed. Last, unsolved questions and potential future directions are described. This review aims to provide a comprehensive reference for future studies, stimulate the formation of new ideas, and promote the generation of new genetic tools in the field of BM/stroke research.
机译：位于循环系统和CNS的界面处，地下室膜（BM）良好定位以调节血脑屏障（BBB）完整性。鉴于BBB在各种神经系统疾病的开发和进展中的重要作用，BM已被假设为有助于这些疾病的发病机制。卒中后，脑血管破裂（出血）或闭塞（缺血）引起的脑血管疾病，BM经历恒定的重塑以调节疾病进展。尽管观察到BM溶解和中风之间的关联，但是每种单独的BM组分在中风后变化，这些组分如何有助于卒中发病机制主要是不清楚的。在本综述中，我首先简要介绍大脑中BM的组成。接下来，总结了BM及其主要成分在稳态条件下的BBB维护中的功能。此外，讨论了BM及其主要成分在出血性和缺血性卒中发病机制中的作用。最后，描述了未解决的问题和潜在的未来方向。本综述旨在为未来的研究提供全面的参考，刺激新想法的形成，并促进BM /卒中研究领域的新遗传工具的产生。

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