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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Blunted cerebrovascular response is associated with elevated beta-amyloid
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Blunted cerebrovascular response is associated with elevated beta-amyloid

机译：钝化脑血管反应与升高的β-淀粉样蛋白有关

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摘要

The goal of this study was to explore the association of beta-amyloid accumulation and cerebrovascular response (CVR) in cognitively normal older adults. Beta-amyloid accumulation was characterized with [18F] Florbetapir positron emission tomography scans. CVR was calculated as middle cerebral artery blood flow velocity change from rest to moderate intensity exercise. We found that individuals with elevated beta-amyloid aggregation had a blunted CVR (n = 25, age 70.1 +/- 4.8; 3.3 +/- 3.7 cm/s) compared to non-elevated individuals (n = 45, age 72.0 +/- 4.9; 7.2 +/- 5.0 cm/s, p 0.001). Further, greater beta-amyloid burden was linearly associated with less CVR across all participants (b = -11.7, p 0.001). Greater CVR and less beta-amyloid burden were associated with processing speed (p 0.05). This study is the first to show that CVR from rest to exercise is blunted across increased global beta-amyloid burden.
机译：本研究的目标是探讨β-淀粉样蛋白积累和脑血管反应（CVR）在认知正常的老年人中的关联。 β-淀粉样蛋白积累的特征在于冒险性冒险积极断层扫描扫描。 CVR计算为中脑动脉血流速度从静止到中等强度运动。 我们发现，与非升高的个体（n = 45，年龄72.0 + / / - 4.9; 7.2 +/- 5.0 cm / s，p <0.001）。 此外，β-淀粉样蛋白负荷较大，与所有参与者的CVR较少（B = -11.7，P <0.001）线性相关。 更大的CVR和更少的β-淀粉样脂蛋白负荷与加工速度有关（P <0.05）。 本研究首先表明CVR休息到锻炼的CVR在增加的全球β-淀粉样脂的增加中易患。

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