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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal aging.
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Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal aging.

机译：定量人类脑中神经感受器：III。 D2样多巴胺受体：理论，验证和正常老化期间的变化。

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摘要

Dopamine receptor density is believed to decline in normal aging. To test this hypothesis, we measured the density of dopamine D2-like receptors in vivo in the neostriatum of normal living humans by using the graphical method. This method determines the D2-like dopamine receptor density in the human brain with an occupying ligand (unlabeled haloperidol) and a radioligand (labeled 3-N-methylspiperone). The method was examined critically, and the assumptions underlying the method were shown to be valid. The validation included comparison of the representation of tracer metabolism by high-pressure liquid chromatography and model assays, calculation of the lumped constant Dw from the value of its components, and comparable tracer partition coefficients in vitro and in vivo. In error analysis, the method consistently performed as well as the direct least-squares regression at statistical noise levels appropriate for the tomograph used in these studies. The method revealed that the density of the D2-like receptors that bind haloperidol in the caudate nucleus of normal humans declined 1% per year after the age of 18 years.
机译：多巴胺受体密度被认为是正常老化的下降。为了测试这一假设，通过使用图形方法，我们测量了正常生活人体的新复合体内的多巴胺D2样受体的密度。该方法用占用配体（未标记的氟哌啶醇）和放射性配体（标记为3-n-甲基哌酮），确定人脑中的D2样多巴胺受体密度。该方法批判性地检查，并且该方法的假设显示有效。该验证包括通过高压液相色谱和模型测定来比较跟踪代谢和模型测定，从其组分的值计算块状恒定DW，以及在体外和体内的可比较示踪分配系数。在误差分析中，该方法在统计噪声水平上始终如一地执行以及在这些研究中使用的断层探测的统计噪声水平的直接比率回归。该方法显示，18岁后，在正常人类的尾核中结合氟哌啶醇的D2样受体的密度下降了1％。

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