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首页> 外文期刊>AIDS >Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia.
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Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia.

机译:患有严重贫血的被HIV感染和未感染的马拉维儿童的红细胞生成。

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摘要

Anemia is common in HIV infection, but the pathophysiology is poorly understood. Bone marrow analysis in 329 severely anemic (hemoglobin <5 g/dl) Malawian children with (n = 40) and without (n = 289) HIV infection showed that HIV-infected children had fewer CD34(+) hematopoietic progenitors (median 10 vs. 15 per thousand, P = 0.04) and erythroid progenitors (2.2 vs. 3.4 per thousand, P = 0.05), but there were no differences in erythrocyte viability and maturation in later stages of erythropoiesis. Despite an HIV-associated reduction in early red cell precursors, subsequent erythropoiesis appears to proceed similarly in HIV-infected and HIV-uninfected children with severe anemia.
机译:贫血在HIV感染中很常见,但对其病理生理学知之甚少。在329名患有(n = 40)和没有(n = 289)HIV感染的严重贫血(血红蛋白<5 g / dl)马拉维儿童中的骨髓分析显示,感染HIV的儿童的造血祖细胞较少,CD34(+)的造血祖细胞较少(中位数为10 vs每千分之15,P = 0.04)和类红细胞祖细胞(2.2与每千分之3.4,P = 0.05),但在红细胞生成的后期,红细胞生存力和成熟度没有差异。尽管HIV相关的早期红细胞前体减少,但随后的红细胞生成似乎在患有严重贫血的HIV感染和未感染HIV的儿童中同样进行。

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