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首页> 外文期刊>AIDS >European mitochondrial DNA haplogroups and liver fibrosis in HIV and hepatitis C virus coinfected patients.
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European mitochondrial DNA haplogroups and liver fibrosis in HIV and hepatitis C virus coinfected patients.

机译：在HIV和丙型肝炎病毒合并感染的患者中，欧洲线粒体DNA单倍体组和肝纤维化。

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BACKGROUND: HIV infection, hepatitis C virus (HCV) liver disease, and mitochondrial DNA (mtDNA) polymorphisms are three possibly interrelated factors that might be associated with progression of liver disease. The aim of this study was to investigate whether mtDNA haplogroups had any influence on liver fibrosis progression in HIV/HCV coinfected patients. METHODS: We carried out a cross-sectional study in 231 patients who were genotyped via Sequenom's MassARRAY platform (San Diego, California, USA). Liver fibrosis was estimated based on the METAVIR score. In each patient, fibrosis progression rate (FPR) was calculated by dividing the fibrosis stage (0-4) by the estimated duration of HCV infection in years. RESULTS: The cluster or major haplogroup HV was significantly associated with reduced odds ratios (OR) for advanced fibrosis [OR 0.35, 95% confidence interval (CI) 0.16-0.77, P = 0.009], cirrhosis (OR 0.16, 95% CI 0.04-0.60, P = 0.007), or high FPR (OR 0.43, 95% CI 0.21-0.84, P = 0.015). Within the major haplogroup HV, haplogroup H was significantly associated with an absence of advanced fibrosis (OR 0.40, 95% CI 0.18-0.91, P = 0.029), cirrhosis (OR 0.14, 95% CI 0.03-0.67, P = 0.014), or high FPR (OR 0.47, 95% CI 0.23-0.95, P = 0.035). We also found a significant association with increased odds of cirrhosis (OR 5.25, 95% CI 1.76-15.64, P = 0.003) in the closely related major haplogroup U. CONCLUSION: The mtDNA haplogroups HV and H were associated with slower fibrosis progression, and the haplogroup U was associated with faster fibrosis progression in HIV/HCV coinfected patients. These data suggest that mtDNA haplogroup may play a significant role in liver fibrogenesis during HCV infection.
机译：背景：HIV感染，丙型肝炎病毒（HCV）肝病和线粒体DNA（mtDNA）多态性是与肝病进展相关的三个可能相互关联的因素。这项研究的目的是调查mtDNA单倍型是否对HIV / HCV合并感染患者的肝纤维化进程有任何影响。方法：我们对231例通过Sequenom's MassARRAY平台（美国加利福尼亚州圣地亚哥）进行基因分型的患者进行了横断面研究。根据METAVIR评分评估肝纤维化。在每位患者中，通过将纤维化阶段（0-4）除以估计的HCV感染持续时间（年）来计算纤维化进展率（FPR）。结果：集群或主要单倍体HV与晚期纤维化[OR 0.35，95％置信区间（CI）0.16-0.77，P = 0.009]，肝硬化（OR 0.16，95％CI 0.04）的降低比值比（OR）显着相关。 -0.60，P = 0.007）或较高的FPR（OR 0.43，95％CI 0.21-0.84，P = 0.015）。在主要单倍型HV中，单倍型H与缺乏晚期纤维化（OR 0.40，95％CI 0.18-0.91，P = 0.029），肝硬化（OR 0.14，95％CI 0.03-0.67，P = 0.014）显着相关，或较高的FPR（OR 0.47，95％CI 0.23-0.95，P = 0.035）。我们还发现在密切相关的主要单倍型U中，肝硬化发生几率显着相关（OR 5.25，95％CI 1.76-15.64，P = 0.003）。结论：mtDNA单倍型HV和H与纤维化进展较慢相关，并且单倍型U与HIV / HCV合并感染患者的纤维化进展更快有关。这些数据表明，mtDNA单倍型可能在HCV感染期间在肝纤维化中发挥重要作用。

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