Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease

Tada Hayato; Kawashiri Masa-aki; Nomura Akihiro; Teramoto Ryota; Hosomichi Kazuyoshi; Nohara Atsushi; Inazu Akihiro; Mabuchi Hiroshi; Tajima Atsushi; Yamagishi Masakazu

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Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease

机译：含钙不生的家族性高胆固醇血症，LDL胆固醇和冠状动脉疾病

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BACKGROUND: The genetic background of severe familial hypercholesterolemia (FH) has yet to be determined.

机译：背景：严重家族高胆固醇血症（FH）的遗传背景尚未确定。

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来源
《Journal of clinical lipidology》 |2018年第6期|共9页
作者
Tada Hayato; Kawashiri Masa-aki; Nomura Akihiro; Teramoto Ryota; Hosomichi Kazuyoshi; Nohara Atsushi; Inazu Akihiro; Mabuchi Hiroshi; Tajima Atsushi; Yamagishi Masakazu;
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作者单位

Kanazawa Univ Grad Sch Med Dept Cardiovasc &

Internal Med 13-1 Takara Machi Kanazawa Ishikawa;

Kanazawa Univ Grad Sch Med Dept Cardiovasc &

Internal Med 13-1 Takara Machi Kanazawa Ishikawa;

Kanazawa Univ Grad Sch Med Dept Cardiovasc &

Internal Med 13-1 Takara Machi Kanazawa Ishikawa;

Kanazawa Univ Grad Sch Med Dept Cardiovasc &

Internal Med 13-1 Takara Machi Kanazawa Ishikawa;

Kanazawa Univ Grad Sch Adv Prevent Med Sci Dept Bioinformat &

Genom Kanazawa Ishikawa Japan;

Kanazawa Univ Grad Sch Med Dept Cardiovasc &

Internal Med 13-1 Takara Machi Kanazawa Ishikawa;

Kanazawa Univ Grad Sch Med Sci Dept Lab Sci Mol Biochem &

Mol Biol Kanazawa Ishikawa Japan;

Kanazawa Univ Grad Sch Med Dept Cardiovasc &

Internal Med 13-1 Takara Machi Kanazawa Ishikawa;

Kanazawa Univ Grad Sch Adv Prevent Med Sci Dept Bioinformat &

Genom Kanazawa Ishikawa Japan;

Kanazawa Univ Grad Sch Med Dept Cardiovasc &

Internal Med 13-1 Takara Machi Kanazawa Ishikawa;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Familial hypercholesterolemia; PCSK9; Genetics; Low-density lipoprotein cholesterol;

机译：家族高胆固醇血症;PCSK9;遗传学;低密度脂蛋白胆固醇;

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专利

1. Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease [J] . Tada Hayato, Kawashiri Masa-aki, Nomura Akihiro, Journal of clinical lipidology . 2018,第6期

机译：含钙不生的家族性高胆固醇血症，LDL胆固醇和冠状动脉疾病
2. Ezetimibe Completely Replaced LDL-Apheresis for the Treatment of Familial Hypercholesterolemia and Coronary Artery Disease after CABG—A Case Report [J] . Ikuo Yokoyama Journal of Biomedical Science and Engineering . 2013,第2期

机译：依泽替米贝完全替代LDL-单采血液透析治疗家族性高胆固醇血症和冠状动脉疾病后CABG —病例报告
3. The potential of mipomersen, an ApoB synthesis inhibitor, to reduce necessity for LDL-apheresis in patients with heterozygous familial hypercholesterolemia and coronary artery disease. [J] . Anja Vogt, Klaus G Parhofer Expert opinion on pharmacotherapy . 2013,第6期

机译：MiPomersen，APOB合成抑制剂的潜力，以减少杂合族家族性高胆固醇血症和冠状动脉疾病患者LDL-leaperesis的必要性。
4. Association between cumulative PFOA exposure and coronary artery disease, hypertension and high cholesterol in community and worker cohorts [C] . Andrea Winquist, Kyle Steenland Annual conference of the International Society of Exposure Science . 2014

机译：累积的PFOA暴露与社区和工人群体中冠状动脉疾病，高血压和高胆固醇之间的关联
5. Structural characterization of a polymorphism in thrombospondin-1 associated with familial premature coronary artery disease. [D] . Hannah, Blue-leaf A. 2004

机译：与家族性早发冠状动脉疾病相关的血小板反应蛋白1多态性的结构表征。
6. Coronary Artery Plaque Regression by a PCSK9 Antibody and Rosuvastatin in Double-heterozygous Familial Hypercholesterolemia with an LDL Receptor Mutation and a PCSK9 V4I Mutation [O] . Ryo Shirahama, Takamichi Ono, Suguru Nagamatsu, 2018

机译：PCSK9抗体和瑞舒伐他汀在具有LDL受体突变和PCSK9 V4I突变的双杂合子家族性高胆固醇血症中的冠状动脉斑块消退
7. Poster Session 1The imaging examination and quality assessmentP185Why did the normal values of the left and right atrial volumes increase in the recent chamber quantification guidelines update?P186Atrial electromechanical delay, Left Atrial mechanical functions and longitudinal left ventricular strain in pre-diabetic patientsP187A web-based platform for e-training in echocardiographyP188Righ atrial size as a marker of success in electrical cardioversion in patients with persistent atrial fibrillationP189Echocardiographic assessment of left atrial dimensions and function in a healthy populationP190Impact of carotid artery revascularization on the cognitive and functional outcome and cerebral flow on TCD and brain MRI in patients with symptomatic carotid artery stenosis: a preliminary reportP191Aortic elasticity is impaired in hypereosinophilic syndromeP192Disturbed intracardiac flow transit prognosticates early decompensation in dilated cardiomyopathyP193Ultrasound guided treatment in acute heart failureP194Determinants of impaired global longitudinal function in middle-aged subjects free of cardiovascular diseaseP195Left ventricular remodeling in asymptomatic heart failure: classification and prognostic evaluationP196Restricted displacement of lateral right ventricular wall: a physiopathological explanation of geometrical and functional cardiac changes after cardiac surgeryP197A novel method to image intracardiac flow stagnation for the risk stratification for thrombosisP198Magnetic resonance imaging of anomalous origin of the left coronary artery from the pulmonary artery in children older than 4 monthsP199Coronary flow reserve is improved by LDL apheresis in patients with familial hypercholesterolemia and chronic ischemic heart diseaseP200 High velocities in the proximal part of the coronary arteries during routine echocardiography can predict nearest prognosisP201Recovery potential of the right ventricular function in the setting of a first STEMI treated by primary PCI: an echocardiographic studyP202Severe aortic stenosis patients with preserved ejection fraction according to flow and gradient classification: prevalence and outcomesP203Is basal left ventricular ejection time able to predict the severity of aortic stenosis in patients with depressed ejection fraction?P204Acceleration time in aortic stenosis: a new echocardiographic diagnostic parameterP205Application of novel Doppler indices of stenosis severity in the assessment of rheumatic mitral stenosis beyond conventional valve area and transvalvular gradientsP206Comparison of conventional echo score in patients with symptomatic rheumatic mitral stenosis: transesophageal echocardiography versus transthoracic echocardiographyP207Speckle-tracking echocardiography in evaluation early left ventricular systolic dysfunction in asymptomatic aortic regurgitation patients with good left ventricular ejection fractionP208Expansible aortic ring annuloplasty: mid-term results of aortic valve repairP209Papillary muscle dysfunction: insights into mitral valve prolapse using speckle tracking imaging [O] . K. Kebed, TAMER Moustafa, R. Conte, 2016

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Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease

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