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首页> 外文期刊>AIDS >Ritonavir-boosted atazanavir exposure is associated with an increased rate of renal stones compared with efavirenz, ritonavir-boosted lopinavir and ritonavir-boosted darunavir.
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Ritonavir-boosted atazanavir exposure is associated with an increased rate of renal stones compared with efavirenz, ritonavir-boosted lopinavir and ritonavir-boosted darunavir.

机译：与依非韦伦，利托那韦增强洛匹那韦和利托那韦增强达洛那韦相比，利托那韦增强的阿扎那韦暴露与肾结石发生率增加相关。

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摘要

There have been no data presented on the relative rates of the development of renal stones in those receiving ritonavir-boosted atazanavir (ATZ/r) when compared with other commonly used antiretrovirals (ARVs). We compared the rate of development of renal stones in a cohort of HIV-infected individuals attending the Chelsea and Westminster Hospital Foundation Trust exposed to ATZ/r with those exposed to efavirenz (EFV)/ritonavir-boosted lopinavir (LPV/r) and ritonavir-boosted darunavir (DRV/r) over a 45-month study period. The rate of development of renal stones in the ATZ/r group (n = 1206) compared with the EFV/LPV/r/DRV/r combined group (n = 4449) was 7.3 [95% confidence interval (CI) 4.7-10.8] per 1000 patient-years and 1.9 (95% CI 1.2-2.8) per 1000 patient-years (P < 0.001), respectively. The renal stones rate remained significantly higher in the ATZ/r group after adjusting for prior ATZ/r/indinavir (IND) exposure. When choosing a boosted protease inhibitor, ATZ/r renal stones should be considered as a potential comorbidity.
机译：与其他常用的抗逆转录病毒药物（ARV）相比，尚无关于利妥那韦增强的阿扎那韦（ATZ / r）的肾结石发展相对速度的数据。我们比较了参加切尔西和威斯敏斯特医院基金会信托的ATZ / r暴露人群与接受依非韦伦（EFV）/利托那韦增强洛匹那韦（LPV / r）和利托那韦暴露于艾滋病毒感染人群的肾结石发生率在45个月的研究期内提高了darunavir（DRV / r）。 ATZ / r组（n = 1206）与EFV / LPV / r / DRV / r联合组（n = 4449）相比，肾结石的发生率为7.3 [95％置信区间（CI）4.7-10.8分别为每1000个患者年和1.9（95％CI 1.2-2.8）每1000个患者年（P <0.001）。调整先前的ATZ / r /茚地那韦（IND）暴露后，ATZ / r组的肾结石发生率仍显着较高。选择增强的蛋白酶抑制剂时，应将ATZ / r肾结石视为潜在的合并症。

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