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HIV incidence among men who have sex with men prescribed postexposure prophylaxis

机译:与男性发生性关系的男性中,经处方预防接触后的艾滋病毒发生率

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摘要

In their correspondence, Puro et at. [1] argue that the difference in incidence we found between the two cohorts in our study could have been confounded by the different 'time at risk'. The fact that the average follow-up time per individual largely differs in both groups is, however, not problematic, as long as the hazard does not depend on follow-up time. We do not think that, in the Amsterdam Cohort Studies (ACS), selection bias due to ' low-risk individuals' remaining in follow-up after 'high-risk individuals' seroconvert is a major problem; the ACS is an open ongoing cohort study, aiming to represent a cohort of MSM living in the. Amsterdam region. Also note that the HIV incidence in the ACS did not decrease over calendar time, which would be expected if the incidence in the population is constant, but only low-risk individuals remain in the study.
机译:在他们的通信中,Puro等人。 [1]认为,我们在研究中发现的这两个队列之间的发病率差异可能被不同的“风险时间”所混淆。但是,只要危害不取决于随访时间,两组的每个人的平均随访时间都存在很大差异这一事实就不成问题。我们不认为,在阿姆斯特丹队列研究(ACS)中,由于“低风险个体”血清转化后仍存在“低风险个体”而导致的选择偏倚并不是主要问题。 ACS是一项正在进行的开放队列研究,旨在代表生活在该地区的MSM队列。阿姆斯特丹地区。还应注意,ACS中的HIV感染率不会在整个日历时间内下降,这是可以预期的,如果该人群中的感染率是恒定的,但是只有低风险个体仍在研究中。

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