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首页> 外文期刊>Biotechnology Advances: An International Review Journal >The insulin-like androgenic gland hormone in crustaceans: from a single gene silencing to a wide array of sexual manipulation-based biotechnologies. (Special Issue: ACB 2011.)
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The insulin-like androgenic gland hormone in crustaceans: from a single gene silencing to a wide array of sexual manipulation-based biotechnologies. (Special Issue: ACB 2011.)

机译:甲壳类动物中的胰岛素样雄激素激素:从单个基因沉默到大量基于性操作的生物技术。 (特刊:ACB2011。)

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摘要

Due to the over-harvesting and deterioration of wild populations, the ever-growing crustacean market is increasingly reliant on aquaculture, driving the need for better management techniques. Since most cultured crustacean species exhibit sexually dimorphic growth patterns, the culture of monosex populations (either all-male or all-female) is a preferred approach for gaining higher yields, with the ecological benefit of reducing the risk of invasion by the cultured species. Sexual manipulations may also render sustainable solutions to the environmental problems caused by the presence of invasive crustacean species with detrimental impacts ranging from aggressive competition with native species for food and shelter, to affecting aquaculture facilities and harvests and causing structural damage to river banks. Recent discoveries of androgenic gland (AG)-specific insulin-like peptides (IAGs) in crustaceans and the ability to manipulate them and their encoding transcripts (IAGs) have raised the possibility of sexually manipulating crustacean populations. Sexual manipulation is already a part of sustainable solutions in fish aquaculture and in the bio-control of insect pest species, and attempts are also being made to implement it with crustaceans. As recently exemplified in a commercially important prawn species, IAG silencing, a temporal, non-genetically modifying and non-transmissible intervention, has enabled the production of non-breeding all-male monosex populations that are the progeny of sexually reversed males ('neo-females'). IAG manipulations-based biotechnologies therefore have the potential to radically transform the entire industry. We review here how this proof of concept could be broadened to meet both aquacultural and environmental needs. We include the major cultured decapod crustacean groups and suggest a sustainable solution for the management of invasive and pest crustacean species. We also review the key considerations for devising a biotechnological approach that specifically tailors the molecular technological abilities to the management of each target group.
机译:由于野生种群的过度捕捞和恶化,不断增长的甲壳类动物市场越来越依赖水产养殖,因此需要更好的管理技术。由于大多数养殖的甲壳类动物都表现出有性的双态生长模式,单性种群(全雄性或全雌性)的养殖是获得较高产量的首选方法,其生态效益是减少了养殖物种入侵的风险。性操作还可能为因存在的甲壳类入侵物种引起的环境问题提供可持续解决方案,其有害影响范围包括与本地物种争夺食物和庇护所,对水产养殖设施和收成的激烈竞争以及对河岸的结构性破坏。甲壳类动物中雄激素腺(AG)特异性胰岛素样肽(IAG)的最新发现以及操纵它们和其编码转录本(IAG)的能力提高了对甲壳类动物种群进行性操作的可能性。性操纵已成为鱼类水产养殖和害虫生物控制中可持续解决方案的一部分,并且也正在尝试将其与甲壳类一起实施。正如最近在商业上重要的对虾物种中所举例说明的那样,IAG沉默是一种暂时的,非遗传的,不可传播的干预措施,已使非繁殖的全男性单性种群得以生产,这些种群是性反转的雄性后代('neo -女性)。因此,基于IAG操纵的生物技术有可能从根本上改变整个行业。我们在这里回顾如何扩展这一概念证明,以满足水产养殖和环境需求。我们包括主要的十足纲甲壳类养殖群体,并提出一种入侵性和害虫甲壳类物种管理的可持续解决方案。我们还回顾了设计生物技术方法的关键注意事项,该方法专门针对每个目标群体的管理量身定制了分子技术能力。

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