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首页> 外文期刊>Journal of chemical neuroanatomy >Aromatase expression and function in the brain and behavior: A comparison across communication systems in teleosts
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Aromatase expression and function in the brain and behavior: A comparison across communication systems in teleosts

机译：大脑和行为中的芳香酶表达和功能：电视中的通信系统比较

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Aromatase (Cyp19a1) is a steroidogenic enzyme that functions to convert aromatizable androgens into bioactive estrogens. The teleost brain is known to have the highest levels of aromatase activity among vertebrates, yet we know relatively little about the function of local estrogen production in teleost behavior. This review compares and contrasts the findings from behavioral studies in the visual, auditory, electrosensory, and olfactory systems, with expression studies in the brain and peripheral nervous system to identify pathways for aromatase effects on teleost behavior. I will first describe aromatase expression at the cellular level in the teleost brain. I will then review evidence for an effect of aromatase activity in sensory perception across different communication systems, followed by a comparison of its effects in the signal production circuitry of vocal and electrogenic teleosts. The findings presented demonstrate that aromatase expression is well conserved in the sensory afferent nerve fibers across communication systems, despite the paucity of study to date on the effects of locally produced estrogens in sensory perception. It is also apparent that there are numerous other locations of aromatase expression within sensory pathways, drawing attention to the need for more localized inhibition studies to understand the function of local estrogen production in distinct regions. The findings in the last section of this review show that differences in vocal call production in the plainfin midshipman fish likely involve differences in aromatase expression in the hindbrain control nucleus, whilst this relationship does not appear to be conserved in the brown ghost knifefish for electromotor production. Therefore, local estrogen function in signaling behavior at the organismal level likely differs between these communication systems, though its effects at the cellular level remain to be determined.
机译：芳族酶（CYP19A1）是一种甾体基酶，其用来将芳香雌激素转化为生物活性雌激素。据称是脊椎动物中具有最高水平的芳族酶活性，但我们对局部雌激素产生的功能相对较少地了解了紧邻行为。该审查与视觉，听觉，电感和嗅觉系统中的行为研究的结果进行了比较和对比，在脑和外周神经系统中表达研究，以鉴定对Textost行为的芳香酶影响的途径。我将首先在紧邻脑中的细胞水平下描述芳族酶表达。然后，我将审查芳香酶活性在不同通信系统中感觉感知的效果的证据，然后进行其在发声和电连接的信号生产电路中的影响。所提出的研究结果表明，尽管迄今为止关于感官感知中局部产生的雌激素的影响，但迄今为止迄今为止缺血在通信系统中的感觉传入神经纤维中，芳香酶的表达良好地保守。显而易见的是，感觉途径中存在许多芳香酶表达的其他位置，提请注意更局部化的抑制研究以了解在不同地区的局部雌激素产生的功能。该评论的最后一部分的调查结果表明，Planefin Midshipman Fish中的声乐呼叫产生的差异可能涉及在后脑控制核中的芳香酶表达的差异，而这种关系似乎在棕色鬼刀中似乎没有用于电动机生产。因此，在机器人水平处的信号传导行为中的局部雌激素功能可能与这些通信系统之间的信号相差，尽管其在蜂窝水平处的效果仍然被确定。

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