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首页> 外文期刊>Journal of chemical neuroanatomy >Axonal degeneration and demyelination following traumatic spinal cord injury: A systematic review and meta-analysis
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Axonal degeneration and demyelination following traumatic spinal cord injury: A systematic review and meta-analysis

机译：创伤性脊髓损伤后轴突变性和脱髓鞘：系统评价和荟萃分析

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摘要

The pathophysiology of spinal cord injury (SCI) related processes of axonal degeneration and demyelination are poorly understood. The present systematic review and meta-analysis were performed such to establish quantitative results of animal studies regarding the role of injury severity, SCI models and level of injury on the pathophysiology of axon and myelin sheath degeneration. 39 related articles were included in the analysis. The compiled data showed that the total number of axons, number of myelinated axons, myelin sheath thickness, axonal conduction velocity, and internode length steadily decreased as time elapsed from the injury (P-for trend < 0.0001). The rate of axonal retrograde degeneration was affected by SCI model and severity of the injury. Axonal degeneration was higher in injuries of the thoracic region. The SCI model and the site of the injury also affected axonal retrograde degeneration. The number of myelinated axons in the caudal region of the injury was significantly higher than the lesion site and the rostral region. The findings of the present meta-analysis show that the pathophysiology of axons and myelin sheath differ in various phases of SCI and are affected by multiple factors related to the injury.
机译：脊髓损伤（SCI）相关过程的轴突变性和脱髓鞘的病理生理学尚不清楚。进行了本发明的系统评价和荟萃分析，以便建立关于损伤严重程度，SCI模型和损伤​​水平对轴突和髓鞘鞘变性的病理生理学的作用的定量结果。 39相关文章被列入分析中。编译的数据显示，随着损伤时间过去的时间（P-FOR趋势<0.0001），轴突数，骨髓轴承数量，骨髓轴颈，骨髓鞘厚度，轴突传导速度和节间长度稳定地减少。轴突逆行变性的速率受SCI模型的影响和损伤的严重程度。胸腔区域损伤轴突变性较高。 SCI模型和损伤​​部位也影响了轴突逆行变性。伤害尾部肿瘤区域中的骨髓轴突的数量明显高于病变部位和振动区域。目前的荟萃分析的发现表明，轴突和髓鞘鞘的病理生理学在SCI的各个阶段不同，受与损伤有关的多种因素的影响。

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