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首页> 外文期刊>Journal of chemical neuroanatomy >Circle of Willis abnormalities and their clinical importance in ageing brains: A cadaveric anatomical and pathological study
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Circle of Willis abnormalities and their clinical importance in ageing brains: A cadaveric anatomical and pathological study

机译：威利斯异常的圈子及其在衰老脑老化中的临床重要性：尸体解剖和病理学研究

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The circle of Willis (CW) located at the base of the brain forms an important collateral network to maintain adequate cerebral perfusion, especially in clinical situations requiring compensatory changes in blood flow. Morphopathological changes in the CW may relate to the severity of the symptoms of certain neurodegenerative and cerebrovascular disorders. The purpose of this study was to investigate the CW abnormalities and their clinical importance in ageing brains. The CW was examined macroscopically in 73 formalin-fixed samples to determine the degree of stenosis of each CW component, atherosclerosis of the CW, hypoplasia (threshold diameter = mild (p = 0.05). However, a significant association was observed between microscopic infarcts in deep white matter and hypoplasia in communicating arteries with Fisher's exact test (p<0.05). Overall, CW abnormalities were predominant in the ageing brains, however their relationships to the occurrence and severity of the symptoms of neurodegenerative pathologies were found to be low.
机译：位于大脑底部的威利斯（CW）圈形成重要的辅助网络，以保持足够的脑灌注，特别是在需要血流补偿变化的临床情况下。 CW的形态病理学变化可能与某些神经变性和脑血管障碍的症状的严重程度有关。本研究的目的是探讨CW异常及其在老化脑中的临床重要性。在73名福尔马林固定样品中宏观检查CW，以确定每个CW组分的狭窄程度，CW的动脉粥样硬化，发育不全（阈值直径=温和（P = 0.05）。然而，在显微镜梗死之间观察到显着的关联深白物质和发育不全在通过Fisher的确切测试沟通（P <0.05）。总体而言，老化脑中的CW异常是主要的，然而，它们与神经变性病理学症状的发生和严重程度的关系是低的。

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