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首页> 外文期刊>Journal of chemical neuroanatomy >Distribution of D-1 and D-2 receptor- immunoreactive neurons in the paraventricular nucleus of the hypothalamus in the rat
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Distribution of D-1 and D-2 receptor- immunoreactive neurons in the paraventricular nucleus of the hypothalamus in the rat

机译：D-1和D-2受体 - 免疫反应神经元在大鼠下丘脑腺内核中的分布

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摘要

The paraventricular nucleus (PVN) of the hypothalamus is an important center in regulating the functions of internal organs, and it is the key nucleus for coordinating endocrine, behavior and autonomic stress responses. Dopamine receptors are widely expressed in the hypothalamus and participate in the regulation of many vital activities, such as blood pressure and glycolipid metabolism, but the details of the cellular localization of dopamine receptors in the PVN are not clear. The present study investigated the distribution of D-1. and D-2 receptorimmunoreactive (IR) neurons in the subnuclei of the PVN and their co-labeling with vasopressin (VP) and oxytocin (OT) in rats by means of Nissl staining and immunofluorescence. The PVN is subdivided into magnocellular and parvicellular subnuclei. The results showed that the D-1 receptor-IR neurons were primarily located in the magnocellular subnuclei and distributed throughout several regions of the PVN, including the paraventricular hypothalamic nucleus, lateral magnocellular part (PaLM), medial magnocellular part (PaMM) and posterior part (PaPO). Additionally, the neurons co-labeled with OT and VP. D-2 receptor-IR neurons had a distribution pattern similar to that of D-1 receptors. The D-1 and D-2-IR neurons in the subnuclei of the PVN were in relatively close proximity to the fomix. Several subnuclei gradually shifted from the ventral medial aspect of the fornix to the dorsal side when examined along the rostrocaudal axis. In summary, D-1 and D-2 receptors are widely distributed in the subnuclei of PVN in a similar distribution pattern with a slightly less number of D-2 receptor immunoreactive neurons than that of D-1. Moreover, D-1 and D-2 receptors are coexisted with VP and OT. The present study provides important morphological evidence for the function of dopamine receptors in the PVN.
机译：下丘脑的椎间盘（PVN）是调节内器官功能的重要中心，并且是协调内分泌，行为和自主应激反应的关键核。多巴胺受体在下丘脑中广泛表达，并参与调节许多重要活动，例如血压和糖脂代谢，但PVN中多巴胺受体的细胞定位细节尚不清楚。本研究研究了D-1的分布。通过NISSL染色和免疫荧光，PVN亚核中的D-2亚核杂环（IR）神经元及其在大鼠中与血管加压素（VP）和催产素（OT）的共标记。 PVN被细分为甲型甲型细胞和术颗粒亚核。结果表明，D-1受体-RINURON主要位于甲型粒细胞亚核中，并在PVN的几个区域分布，包括椎间露下丘脑核，侧粒细胞部分（PAMP），内侧甲型颗粒部分（PAMM）和后部（Papo）。另外，用OT和VP共标记的神经元。 D-2受体 - IR神经元具有与D-1受体类似的分布模式。 PVN亚核中的D-1和D-2-IR神经元对FOMIX的亚核相对近。当沿着rostrocaudal轴检查时，几个亚核从腹侧腹侧腹侧方面逐渐移位到背侧。发明内容中，D-1和D-2受体广泛分布在类似的分布图中在PVN的亚核中分布，其与D-2的D-2​​受体免疫反应性神经元略小于D-1。此外，D-1和D-2受体与VP和OT共存。本研究为PVN中的多巴胺受体的功能提供了重要的形态学证据。

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  • 来源
    《Journal of chemical neuroanatomy》 |2019年第2019期|共7页
  • 作者

    Ran Xuerui; Yang Yanli; Meng Yamei; Li Yong; Zhou Li; Wang Zhiyong; Zhu Jinxia;

  • 作者单位

    Xinxiang Med Univ Dept Human Anat Xinxiang Key Lab Mol Neurol Xinxiang 453003 Henan Peoples R;

    Xinxiang Med Univ Dept Human Anat Xinxiang Key Lab Mol Neurol Xinxiang 453003 Henan Peoples R;

    Xinxiang Med Univ Dept Human Anat Xinxiang Key Lab Mol Neurol Xinxiang 453003 Henan Peoples R;

    Xinxiang Med Univ Dept Human Anat Xinxiang Key Lab Mol Neurol Xinxiang 453003 Henan Peoples R;

    Xinxiang Med Univ Dept Human Anat Xinxiang Key Lab Mol Neurol Xinxiang 453003 Henan Peoples R;

    Xinxiang Med Univ Dept Human Anat Xinxiang Key Lab Mol Neurol Xinxiang 453003 Henan Peoples R;

    Xinxiang Med Univ Dept Human Anat Xinxiang Key Lab Mol Neurol Xinxiang 453003 Henan Peoples R;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

    Paraventricular nucleus; Dopamine receptor; Dopamine; Subnuclei;

    机译：椎间盘核;多巴胺受体;多巴胺;亚核;

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