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首页> 外文期刊>Journal of chemical neuroanatomy >Autoradiographic localization and binding study of benzodiazepines receptor sites in carp brain (Cyprinus carpio L.).
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Autoradiographic localization and binding study of benzodiazepines receptor sites in carp brain (Cyprinus carpio L.).

机译：鲤鱼脑（Cyprinus carpio L.）中苯并二氮杂卓疫苗受体遗址的放射性分析及结合研究。

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This study demonstrates, for the first time, by both autoradiography and binding assay that [3H]Ro 15-1788 binds to carp brain with a high degree of anatomical selectivity. Saturation binding of the radioligand was determined in seven anatomically defined regions and suggested the presence of one class of binding sites (Type I-lke). In general, there was a good correlation between the autoradiographic and the binding data. By far, the optic tectum and the vagal, facial, and glossopharyngeal lobes showed the majority of [3H]Ro 15-1788 binding sites. Low to negative concentration of binding sites was detected in the cerebellum. The location of [3H]Ro 15-1788 binding sites in particular brain regions, indicates that benzodiazepine receptors could be associated with pathways involved in the control of basic central functions as spatial learning acquisition and retention, and feeding behaviour.
机译：本研究首次通过放射造影和结合测定来证明[3H] RO 15-1788与高度解剖选择性结合的鲤鱼脑结合。 在七个解剖学定义的区域中测定放射性配体的饱和结合，并表明存在一类结合位点（I型-LKe）。 通常，auterAcroprographic与绑定数据之间存在良好的相关性。 到目前为止，视神经和阴道，面部，术语和肾小球裂隙率为大部分[3H] RO 15-1788结合位点。 在小脑中检测到粘合位点的低于负浓度。 特别是脑区域的[3H] RO 15-1788结合位点的位置表明苯二氮卓受体可能与涉及基本中央功能控制的途径相关，作为空间学习获取和保留，以及喂养行为。

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