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首页> 外文期刊>AIDS >Prospective study of bone mineral density changes in aging men with or at risk for HIV infection.
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Prospective study of bone mineral density changes in aging men with or at risk for HIV infection.

机译：对患有艾滋病毒或有感染艾滋病毒风险的老龄人骨矿物质密度变化的前瞻性研究。

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OBJECTIVE: To investigate rates and predictors of change in bone mineral density (BMD) in a cohort of aging men with or at risk for HIV infection. DESIGN: A prospective cohort study among 230 HIV-infected and 159 HIV-uninfected men aged at least 49 years. METHODS: Longitudinal analyses of annual change in BMD at the femoral neck, total hip, and lumbar spine. RESULTS: At baseline, 46% of men had normal BMD, 42% had osteopenia, and 12% had osteoporosis. Of those men with normal BMD, 14% progressed to osteopenia and 86% continued to have normal BMD. Of the men initially with osteopenia, 12% progressed to osteoporosis and 83% continued to have osteopenia. Osteopenia incidence per 100 person-years at risk was 2.6 for HIV-uninfected men and 7.2 for HIV-infected men; osteoporosis incidence was 2.2 per 100 person-years at risk among men with osteopenia, regardless of HIV status. In multivariable analysis of annual change in BMD at the femoral neck, we found a significant interaction between heroin use and AIDS diagnosis, such that the greatest bone loss occurred with both AIDS and heroin use (adjusted predicted mean annual bone loss 0.0196 g/cm). Hepatitis C virus seropositivity was also associated with femoral neck bone loss (P = 0.04). The interaction between AIDS and heroin use also was associated with bone loss at the total hip, as was current methadone use (P < 0.01). CONCLUSION: We found an association of heroin use and AIDS with BMD change, suggesting that heroin users with AIDS may be at particular risk for bone loss.
机译：目的：调查一群患有艾滋病毒或有感染艾滋病毒风险的老龄人群的骨矿物质密度（BMD）变化率和预测因子。设计：前瞻性队列研究在230名感染艾滋病毒和159名未感染艾滋病毒的男性中进行，年龄至少49岁。方法：纵向分析股骨颈，全髋和腰椎骨密度的年度变化。结果：基线时，46％的男性BMD正常，42％的骨质减少，12％的骨质疏松。在BMD正常的男性中，有14％进展为骨质减少，而86％的BMD仍正常。在最初患有骨质减少的男性中，有12％进展为骨质疏松，而83％继续患有骨质减少。未感染艾滋病毒的男性每100人年的骨质减少症发生率为2.6，而感染艾滋病毒的男性为7.2。骨质疏松症男性的骨质疏松症发生率为每100人年2.2例，而与HIV状况无关。在对股骨颈BMD年度变化的多变量分析中，我们发现海洛因使用与AIDS诊断之间存在显着的相互作用，使得艾滋病和海洛因使用均造成最大的骨质流失（调整后的预测平均年骨质丢失量为0.0196 g / cm） 。丙型肝炎病毒血清阳性还与股骨颈骨丢失有关（P = 0.04）。艾滋病和海洛因使用之间的相互作用也与整个髋关节的骨质流失相关，目前使用美沙酮的情况也是如此（P <0.01）。结论：我们发现使用海洛因和艾滋病与BMD变化有关，这表明患有海洛因的艾滋病患者可能特别容易发生骨质流失。

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