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首页> 外文期刊>Journal of Comparative Pathology >Loss of Endothelial Barrier Antigen Immunoreactivity in Rat Retinal Microvessels is Correlated with Clostridium perfringens Type D Epsilon Toxin-induced Damage to the Blood-Retinal Barrier
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Loss of Endothelial Barrier Antigen Immunoreactivity in Rat Retinal Microvessels is Correlated with Clostridium perfringens Type D Epsilon Toxin-induced Damage to the Blood-Retinal Barrier

机译：大鼠视网膜微血管中内皮屏障抗原免疫反应性与流量蛋白毒素毒素造成的血质视网膜屏障损伤相关

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摘要

Clostridium perfringens type D epsilon toxin (ETX) is a potent neurotoxin producing a severe, and often fatal, neurological disorder in ruminant livestock. Microvascular damage appears to be the fundamental action of ETX in the brain and, recently, similar vascular injury, with subsequent severe vasogenic oedema, has been reported in the retina of rats given ETX. Endothelial barrier antigen (EBA) is a useful marker of an intact blood brain barrier in rats and it has been shown that loss of EBA immunoreactivity is correlated with ETX-induced cerebral microvascular damage in this species. This paper reports, for the first time, that loss of EBA immunoexpression also occurs in rat retinal microvessels exposed to ETX, the marked reduction in EBA immunopositivity acting as a useful marker for blood-retinal barrier breakdown produced by this neurotoxin. (C) 2017 Elsevier Ltd. All rights reserved.
机译：Clostridium perfringens型D epsilon毒素（Etx）是一种强大的神经毒素，在反刍动物牲畜中产生严重，通常是致命的神经疾病。 微血管损伤似乎是ETX在大脑中ETX的基本作用，最近，在给予ETX的大鼠视网膜中报道了随后的严重血管生成水肿的类似血管损伤。 内皮屏障抗原（EBA）是大鼠完整血脑屏障的有用标志物，已经表明，EBA免疫反应性的丧失与该物种中的ETX诱导的脑微血管损伤相关。 本文报告称，在暴露于ETX的大鼠视网膜微血管中也发生了EBA免疫表达的丧失，EBA免疫阳性的标记降低作用作为该神经毒素产生的血质视网膜阻隔击穿的有用标志物。 （c）2017 Elsevier Ltd.保留所有权利。

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