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Micro- and nanodevices integrated with biomolecular probes

机译：集成了生物分子探针的微纳设备

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摘要

Understanding how biomolecules, proteins and cells interact with their surroundings and other biological entities has become the fundamental design criterion for most biomedical micro- and nanodevices. Advances in biology, medicine, and nanofabrication technologies complement each other and allow us to engineer new tools based on biomolecules utilized as probes. Engineered microanosystems and biomolecules in nature have remarkably robust compatibility in terms of function, size, and physical properties. This article presents the state of the art in micro- and nanoscale devices designed and fabricated with biomolecular probes as their vital constituents. General design and fabrication concepts are presented and three major platform technologies are highlighted: microcantilevers, microanopillars, and microfluidics. Overview of each technology, typical fabrication details, and application areas are presented by emphasizing significant achievements, current challenges, and future opportunities. (C) 2015 Elsevier Inc. All rights reserved.
机译：了解生物分子，蛋白质和细胞如何与周围环境和其他生物实体相互作用已经成为大多数生物医学微纳米设备的基本设计准则。生物学，医学和纳米制造技术的进步相辅相成，使我们能够基于用作探针的生物分子设计出新的工具。工程化的微/纳米系统和生物分子在功能，尺寸和物理特性方面具有非常强大的兼容性。本文介绍了以生物分子探针作为其重要成分设计和制造的微米和纳米级设备的最新技术。介绍了一般的设计和制造概念，并重点介绍了三种主要的平台技术：微悬臂梁，微/纳米支柱和微流体技术。通过强调重要的成就，当前的挑战和未来的机会，介绍了每种技术的概述，典型的制造细节和应用领域。 （C）2015 Elsevier Inc.保留所有权利。

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