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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >High incidence of severe neurological manifestations and high mortality rate for adult Listeria monocytogenes meningitis in Taiwan
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High incidence of severe neurological manifestations and high mortality rate for adult Listeria monocytogenes meningitis in Taiwan

机译：严重神经系统表现的高发病率和台湾成人李斯特菌单核细胞增强脑膜炎的高死亡率

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摘要

The clinical characteristics and therapeutic outcomes of adult Listeria monocytogenes meningitis are not commonly examined in isolation in the literature. During a study period of 19 years (2000-2018), 366 patients with culture-proven adult bacterial meningitis (ABM) were identified in the author's hospital (264 patients in 2000-2010 and 102 patients in 2011-2018). Of the 366 ABM patients, 330 had monomicrobial infections while the other 36 had mixed infections. L. monocytogenes infection was identified in 11 of the 330 patients with monomicrobial ABM (3 in 2000-2010 and 8 in 2011-2018). These 11 patients included 5 males and 6 females, aged 47 to 76 years (median age = 61.7). None of the 11 patients had a postneurosurgical state as the underlying cause, but 3 of them contracted the infection nosocomially. Common underlying conditions included liver cirrhosis (4), systemic malignancy (3), diabetes mellitus (3), and renal disease (2). The most common clinical manifestations were fever (11), altered consciousness (8), seizure (8), bacteremia (7) and hydrocephalus (5). The therapeutic result revealed a mortality rate of 72.7% (8/11), but no significant prognostic factors were identified. The clinical features of 8 additional Taiwanese L. monocytogenes ABM patients reported in the literature, were also included for analysis. The present study revealed an increase in L. monocytogenes ABM in recent years and most patients presented with severe neurological manifestations. The current study is a preliminary overview of L. monocytogenes meningitis in adults and a further large-scale study is needed for improved delineation of this specific infectious syndrome. (C) 2019 Elsevier Ltd. All rights reserved.
机译：成人李斯特菌单核细胞增生脑膜炎的临床特征和治疗结果不常见于文献中的分离。在19年（2000-2018）的研究期间，作者医院中发现了36​​6例培养的成年细菌脑膜炎（ABM）（2000-2010年的26​​4名患者，2011-2018患者）。在366名ABM患者中，330例有单体性感染，而其他36次具有混合感染。 L.单核细胞增生感染于330例单体血症ABM的11例（2000-2010和2011-2018）中的11例中鉴定出感染。这11名患者包括5名男性和6名女性，年龄47至76岁（中位年龄= 61.7）。 11名患者中没有一个导致后胸癌作为潜在的原因，但其中3个患者缩定了疑虑的感染。常见的潜在条件包括肝硬化（4），全身恶性肿瘤（3），糖尿病（3）和肾病（2）。最常见的临床表现是发烧（11），改变意识（8），癫痫发作（8），菌血症（7）和脑积水（5）。治疗结果显示出72.7％（8/11）的死亡率，但没有确定显着的预后因素。在文献中报告的8个额外的台湾L.单核细胞增生ABM患者的临床特征也被包括分析。本研究表明，近年来L.单核细胞增生症ABM增加，大多数患者具有严重的神经表现。目前的研究是L.单核细胞增生的初步概述成人脑膜炎，并且需要进一步的大规模研究来改善这种特定传染综合征的描绘。 （c）2019年elestvier有限公司保留所有权利。

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