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首页> 外文期刊>AIDS >A study of rectal mucosa administration of IL-2 in treatment of HIV/AIDS: a novel method for the treatment of HIV/AIDS
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A study of rectal mucosa administration of IL-2 in treatment of HIV/AIDS: a novel method for the treatment of HIV/AIDS

机译：直肠粘膜给药IL-2治疗HIV / AIDS的研究：治疗HIV / AIDS的新方法

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The clinical course of AIDS was drastically changed in the 1990s with the advent of highly active antiretroviral therapy (HAART). It led to sustained reductions in HIV-1 replication, rise in CD4~+ T-cell count, and concomitant immune reconstitution, resulting in significant reductions in morbidity and mortality. These benefits, however, have been achieved at the cost of considerable drug toxicity and monetary expense. Particularly disheartening is the realization that HAART alone will not cure HIV-1 infection because of the existence ofpersistent viral reservoirs, which ultimately rekindle viral replication once therapy is stopped. So, to explore a new idea to control AIDS effectively thereby has become an urgent need. As summarized in all clinical research in the area of AIDS treatment in these years, interleukin (IL)-2 is considered to be effective, though there have been conflicting reports.
机译：到了1990年代，随着高效抗逆转录病毒疗法（HAART）的出现，艾滋病的临床病程发生了巨大变化。它导致HIV-1复制的持续减少，CD4〜+ T细胞计数的增加以及伴随的免疫重建，从而大大降低了发病率和死亡率。然而，这些益处是以相当大的药物毒性和金钱费用为代价的。特别令人沮丧的是，认识到仅HAART不能治愈HIV-1感染，因为存在持久的病毒库，一旦停止治疗，病毒库最终会重新点燃病毒复制。因此，探索一种有效控制艾滋病的新思路已成为当务之急。近年来，在艾滋病治疗领域的所有临床研究中都总结出，白介素（IL）-2被认为是有效的，尽管有相互矛盾的报道。

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