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首页> 外文期刊>Journal of clinical laboratory analysis. >Serum carcinoembryonic antigen is positively associated with leukocyte count in Korean adults
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Serum carcinoembryonic antigen is positively associated with leukocyte count in Korean adults

机译：血清癌胚抗原与韩国成年人的白细胞计数正相关

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Background Emerging evidence shows that serum carcinoembryonic antigen ( CEA ) levels may modestly be increased in non‐neoplastic conditions such as cardiometabolic diseases, which are increasingly being seen as inflammatory diseases. Leukocyte count is widely evaluated marker of inflammation in clinical practice and a useful predictor of cardiometabolic disease. In this study, we aimed to determine the relationship between serum CEA levels and leukocyte counts in Korean adults. Methods This cross‐sectional study included a total of 19?834 individuals enrolled from a health promotion center between November 2006 and July 2010. Multiple linear regression analysis was performed to investigate the association between serum CEA levels and leukocyte counts after adjusting for confounding variables. Results According to both stepwise‐method and enter‐method multiple linear regression analyses, serum CEA levels were positively and independently associated with leukocyte counts ( P .001) after adjusting for age, sex, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, HDL ‐cholesterol, cigarette smoking, alcohol ingestion, physical activity, diabetes mellitus, and anti‐inflammatory drugs. Conclusions We demonstrate a positive relationship between serum CEA levels and leukocyte counts in Korean adults. Our results suggested that an elevated serum CEA level may reflect chronic inflammation state.
机译：背景技术出现的证据表明，在非肿瘤条件如心细素疾病等非肿瘤条件下，血清癌胚抗原（CEA）水平可能越来越多地被视为炎症性疾病。白细胞计数广泛评估临床实践中炎症的标志物和心细素疾病的有用预测因子。在这项研究中，我们旨在确定韩国成年人血清CEA水平与白细胞计数的关系。方法这一横断面研究还包括从2006年11月和2010年7月之间从健康促进中心注册的19岁？834个人。进行了多元线性回归分析以研究血清CEA水平与白细胞计数在调整混淆变量后的关联。结果根据逐步方法和进纸方法多元线性回归分析，血清CEA水平呈正且独立地与白细胞计数（P <.001）调整为年龄，性别，体重指数，收缩压，舒张症后血压，总胆固醇，甘油三酯，HDL -Choleterol，吸烟，酒精摄取，身体活动，糖尿病和抗炎药。结论我们展示了韩国成年人血清CEA水平与白细胞计数的阳性关系。我们的研究结果表明，血清CEA水平升高可能反映慢性炎症状态。

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