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首页> 外文期刊>Journal of clinical laboratory analysis. >Can neutrophil to lymphocyte ratio predict late‐onset sepsis in preterm infants?
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Can neutrophil to lymphocyte ratio predict late‐onset sepsis in preterm infants?

机译：淋巴细胞比率可以预测早产儿的晚期脓毒症吗？

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Background The neutrophil to lymphocyte ratio ( NLR ) is an easily accessible biomarker that has been reported to represent disease severity in adult trials. The aim of this study was to evaluate the relationship between culture positiveness and NLR in cases where the reason of sepsis was considered, and to foresight an idea about the active agents. Methods Preterm infants with birth weights ≤1500?g and/or ≤32 gestational weeks were eligible for this study. The postnatal age of all included infants was more than 3?days with clinical and laboratory signs of sepsis. According to the results of blood cultures, all enrolled infants were classified into 2 groups: the culture‐proven septic infants and suspected septic infants. The NLR was calculated as the ratio of neutrophil count to lymphocyte count. Initial laboratory investigations included WBC count, platelet count ( PLT ), C‐reactive protein (CRP), and blood cultures. Results A total of 127 infants were involved: 57 culture‐proven sepsis and 75 suspected sepsis. There were no significant differences between groups regarding gestational age, gender, birth weight, delivery mode, and postnatal age. Receiver operating curve analysis for NLR and CRP was calculated. The area under the curve corresponded to 0.78?±?0.04 ( NLR ) vs 0.55?±?0.05 (CRP). Using a cutoff point of 1.77 for NLR , the sensitivity was 0.73, the specificity was 0.78, and accuracy rate was 0.76. Discussion The prediction of NLR , an easy, inexpensive, and rapid method, along with CRP in the neonatal period for diagnosis of sepsis, will be more effective in detecting culture‐proven sepsis and in decreasing unnecessary antibiotherapy.
机译：背景技术中性粒细胞与淋巴细胞比（NLR）是一种易于访问的生物标志物，据报道，代表成人试验中的疾病严重程度。本研究的目的是评估文化阳性和NLR之间的关系，因为在考虑了败血症的原因，并对有关活性剂的想法进行了解。方法使用出生体重≤1500？g和/或≤32孕胎的早产儿有资格参加本研究。所有包括婴儿的后期年龄超过3.患有肠脓毒症的临床和实验室症状。根据血液培养的结果，将所有注册的婴儿分为2组：文化证明的化粪池婴儿和疑似脓毒症婴儿。计算NLR作为中性粒细胞计数与淋巴细胞计数的比率。初始实验室研究包括WBC计数，血小板计数（PLT），C反应蛋白（CRP）和血液培养。结果共有127名婴儿参与其中：57种文化证明脓毒症和75名疑似脓毒症。关于胎龄，性别，出生体重，交付模式和产后年龄之间的群体之间没有显着差异。计算了NLR和CRP的接收器操作曲线分析。曲线下的区域对应于0.78≤0.04（NLR）Vs 0.55？±0.05（CRP）。使用1.77的截止点对于NLR，灵敏度为0.73，特异性为0.78，精度率为0.76。讨论NLR的预测，简单，廉价和快速的方法以及新生儿时期的CRP诊断败血症，在检测文化证明的败血症和降低不必要的抗疗法时将更有效。

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