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首页> 外文期刊>Journal of clinical laboratory analysis. >Association between urine retinol‐binding protein levels and nonalcoholic fatty liver disease: A cross‐sectional study in Chinese population
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Association between urine retinol‐binding protein levels and nonalcoholic fatty liver disease: A cross‐sectional study in Chinese population

机译：尿尿醇结合蛋白水平与非酒精性脂肪肝病之间的关系：中国人群的横截面研究

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Objective The prevalence of nonalcoholic fatty liver disease ( NAFLD ) has been rapidly increased, becoming a public health problem worldwide. Our objective was to investigate the association between urine retinol‐binding protein ( RBP ) and NAFLD in a Chinese population and develop a multivariate logistic regression model for NAFLD prediction. Methods A total of 317 NAFLD patients and 391 healthy controls were enrolled in this cross‐sectional study based on inclusion and exclusion criteria, from whom fasting urine and blood were collected for further study. Urine RBP level and other parameters were measured and compared between NAFLD subjects and controls. Results Urine RBP levels (expressed by RBP /creatinine ratio) in NAFLD patients were significantly higher than controls (median 133.1?mg/g vs 110.7?mg/g; P ??.001). Urine RBP /creatinine ratio was verified as an independent factor for NAFLD prediction after adjustment in multivariate logistic regression. The area under curve ( AUC ) of receiver operating characteristic ( ROC ) was 0.889 with the 95% confidence interval from 0.867 to 0.912.With a cutoff point of 0.215, the sensitivity and specificity of urine RBP /creatinine ratio in NAFLD prediction were 81.1% and 84.5%, respectively. Conclusion Our results demonstrated that urine RBP /creatinine ratio was an independent risk factor for NAFLD while the predictive model for NAFLD diagnosis is noninvasive with high sensitivity and specificity.
机译：目的非酒精性脂肪肝病（NAFLD）的患病率已迅速增加，全球成为公共卫生问题。我们的目的是探讨中国人口中尿视黄醇结合蛋白（RBP）和NAFLD之间的关联，并为NAFLD预测开发多元逻辑回归模型。方法基于纳入和排除标准，共纳入了317名NAFLD患者和391名健康对照，从收集了尿液和血液中进行进一步研究。测量尿RBP水平和其他参数，并在NAFLD受试者和对照之间进行比较。结果NAFLD患者中尿的RBP水平（由RBP /肌酐比表达）显着高于对照（中值133.1×mg / g vs110.7×mg / g;p≤001）。尿液/肌酐比率被验证为多变量逻辑回归调整后NAFLD预测的独立因素。接收器操作特性（ROC）的曲线（AUC）下的区域为0.889，95％置信区间从0.867〜0.912。截止点为0.215，尿液RBP /肌酐比率在NAFLD预测中的敏感性和特异性为81.1％分别为84.5％。结论我们的结果表明，尿液/肌酐比率是NAFLD的独立危险因素，而NAFLD诊断的预测模型是具有高敏感性和特异性的非侵入性。

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