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首页> 外文期刊>AIDS >Infectiousness of HIV-infected men who have sex with men in the era of highly active antiretroviral therapy.
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Infectiousness of HIV-infected men who have sex with men in the era of highly active antiretroviral therapy.

机译：在高效抗逆转录病毒疗法时代，与男性发生性关系的受艾滋病毒感染的男性具有传染性。

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摘要

In the majority of resource-rich countries, the most common exposure route for HIV transmission is unprotected anal intercourse among homosexual men [1,2]. HIV diagnosis rates in these settings have been increasing over the last decade [1-3], which is somewhat paradoxical considering that effective combination antiretroviral therapy (ART) has had increasing coverage. There is evidence among heterosexuals of a positive association between viral load and infectiousness [4-6], and use of ART has been shown to reduce HIV transmission risk among discordant couples [7]. Further, both a recent meta-analysis [6] and a prospective cohort study [8] calculated a remarkably similar reduction, of 92%, in HIV transmission rates from heterosexual men and women who are treated compared with those who are untreated. It might be expected that ART would also reduce HIV transmission rates among homosexual men, but the fact that the per-contact probability of HIV transmission through anal intercourse is more than 10-fold higher than by vaginal intercourse means that results may not necessarily be the same.
机译：在大多数资源丰富的国家中，最常见的HIV传播途径是同性恋男性之间不受保护的肛交[1,2]。在过去十年中，这些情况下的HIV诊断率一直在上升[1-3]，考虑到有效的联合抗逆转录病毒疗法（ART）的覆盖率不断提高，这有点自相矛盾。有证据表明，异性恋者之间的病毒载量和传染性之间存在正相关性[4-6]，并且已证明使用抗逆转录病毒疗法可以减少不和谐夫妻之间的艾滋病毒传播风险[7]。此外，最近的一项荟萃​​分析[6]和一项前瞻性队列研究[8]计算出，与未接受治疗的异性恋者相比，接受治疗的异性恋男女的HIV传播率显着相似地降低了92％。可以预期，抗逆转录病毒疗法也将降低同性恋男性之间的HIV传播率，但是事实表明，通过肛门性交传播HIV的每次接触概率比通过阴道性交传播的HIV高10倍以上，这意味着结果不一定是相同。

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