Persistent immune activation in chronic HIV infection: do any interventions work?

Reena Rajasuriar; Gabriela Khoury; Adeeba Kamamlzaman; Martyn A. French; Paul U. Cameron; Sharon R. Lewin

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Persistent immune activation in chronic HIV infection: do any interventions work?

机译：在慢性HIV感染中持续的免疫激活：任何干预措施有效吗？

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Introduction: The availability of combination antiretroviral therapy (cART) has led to substantial reduction in morbidity and mortality in HIV-infected patients; however, life expectancy remains reduced especially in HIV-infected patients who initiate cART with CD4 T-cell counts less than 200 cells/mul. Increased immune activation in patients on long-term suppressive cART has been associated with increased mortality and both AIDS and non-AIDS-defming illnesses, suggesting that chronic immune activation may have a potential role in driving increased morbidity and mortality.

机译：简介：联合抗逆转录病毒疗法（cART）的可用性已大大降低了HIV感染患者的发病率和死亡率。但是，预期寿命仍然降低，特别是在感染CD4 T细胞计数低于200个细胞/ mul的cART的HIV感染患者中。长期使用抑制性cART的患者体内的免疫激活增加与死亡率增加以及AIDS和非AIDS疾病均相关，这表明慢性免疫激活可能在增加发病率和死亡率方面具有潜在作用。

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《AIDS》 |2013年第8期|共10页
作者
Reena Rajasuriar; Gabriela Khoury; Adeeba Kamamlzaman; Martyn A. French; Paul U. Cameron; Sharon R. Lewin;
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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
chronic immune activation; combination antiretroviral therapy; HIV; non-AIDS-defining illness; T-cell activation;

机译：慢性免疫激活;联合抗逆转录病毒疗法;艾滋病毒;非艾滋病定义疾病;T细胞激活;

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1. Persistent immune activation in chronic HIV infection: do any interventions work? [J] . Reena Rajasuriar, Gabriela Khoury, Adeeba Kamamlzaman, AIDS . 2013,第8期

机译：在慢性HIV感染中持续的免疫激活：任何干预措施有效吗？
2. Innate immunity and chronic immune activation in HCV/HIV-1 co-infection. [J] . Gonzalez VD, Landay AL, Sandberg JK Clinical immunology: The official journal of the Clinical Immunology Society . 2010,第1期

机译：HCV / HIV-1共感染中的先天免疫和慢性免疫激活。
3. Therapeutic immunisation plus cytokine and hormone therapy improves CD4 T-cell counts, restores anti-HIV-1 responses and reduces immune activation in treated chronic HIV-1 infection [J] . Herasimtschuk Anna, Downey Jocelyn, Nelson Mark, Vaccine . 2014,第51期

机译：治疗性免疫加上细胞因子和激素疗法可改善CD4 T细胞计数，恢复抗HIV-1反应并减少已治疗的慢性HIV-1感染中的免疫激活
4. To boost or not to boost: Immune activation in HIV infection [C] . Shu Zhan, Middleton Richard H., Chen Michael Z.Q. European Control Conference . 2014

机译：增强或不增强：HIV感染中的免疫激活
5. Regulatory T Cells and Immune Activation in the Mucosa During Chronic HIV- and SIV- Infection: Evidence for Immune-mediated Suppression During Progressive Infection [D] . Shaw, Julia Marie 2011

机译：慢性HIV和SIV感染过程中粘膜中的调节性T细胞和免疫激活：渐进感染过程中免疫介导的抑制的证据。
6. Persistent immune activation in chronic HIV infection: do any interventions work? [O] . Reena Rajasuriar, Gabriela Khoury, Adeeba Kamarulzaman, -1

机译：在慢性HIV感染中持续的免疫激活：任何干预措施有效吗？
7. Persistent immune activation in chronic HIV infection: Do any interventions work? [O] . Rajasuriar R., Khoury G., Kamarulzaman A., 2013

机译：慢性HIV感染中持续的免疫激活：任何干预措施有效吗？

Persistent immune activation in chronic HIV infection: do any interventions work?

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