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首页> 外文期刊>Journal of clinical densitometry >Precision of Second-Generation High-Resolution Peripheral Quantitative Computed Tomography: Intra- and Intertester Reproducibilities and Factors Involved in the Reproducibility of Cortical Porosity
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Precision of Second-Generation High-Resolution Peripheral Quantitative Computed Tomography: Intra- and Intertester Reproducibilities and Factors Involved in the Reproducibility of Cortical Porosity

机译：第二代高分辨率外围定量计算断层扫描的精度：涉及和中期终端的恶作剧和涉及皮质孔隙率的再现性的因素

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High-resolution peripheral quantitative computed tomography (HR-pQCT) was upgraded to a second generation in 2014 with higher spatial resolution, faster scan time, and a different measurement algorithm. The purpose of this study was to investigate the precision of the second-generation HR-pQCT. The distal radius and tibia of 15 healthy men and women (age range of 20-74 yr, 8 men and 7 women) were scanned by second generation HR-pQCT, and their geometry, bone mineral density (BMD), and the microstructure of trabecular and cortical bones were evaluated. Scans and measurements were performed by tester 1 at baseline and at 1 and 4 wk to evaluate intratester reproducibility, and by testers 2 and 3 one time each to evaluate intertester reproducibility. Reproducibility was evaluated by root mean square percent coefficient of variance (RMS %CV). Factors involved in the reproducibility of cortical porosity (Ct.Po) were also investigated. The ranges of RMS%CV were 0.2%-2.5% for geometry, 0.6%-1.7% for BMD, 0.7%-2.4% for trabecular bone, and 1.1%-1.3% for cortical thickness, showing excellent reproducibility. The range of RMS%CV for Ct.Po was 11.0%-13.3%, relatively higher than those for the other parameters. There was no apparent difference between intra- and intertester reproducibilities. There was no clear correlation between the percent coefficient of variance of Ct.Po and the subjects' background characteristics, motion artifact, and cortical bone structure. The reproducibility of the second-generation HR-pQCT was excellent in geometry, BMD, trabecular bone, and cortical thickness, with no apparent difference between intra- and intertester reproducibilities. Compared with the first generation HR-pQCT, the reproducibility of trabecular bone was improved. The reproducibility of Ct.Po was insufficient and needed to be improved, and factors that influence its reproducibility were not clear.
机译：高分辨率外围定量计算断层扫描（HR-PQCT）升级到2014年的第二代，空间分辨率更快，扫描时间更快，扫描时间和不同的测量算法。本研究的目的是研究第二代HR-PQCT的精度。第二代HR-PQCT扫描了15名健康男女的远端和胫骨（20-74岁，8名男子和7名女性），以及它们的几何，骨矿物密度（BMD）和微观结构扫描评估小梁和皮质骨骼。扫描和测量由基线和1和4周的测试仪1进行，以评估肠内蛋白的再现性，并通过测试仪2和3一次性来评估interster可再现性。通过均方根百分比的方差系数（RMS％CV）进行再现性。还研究了涉及皮质孔隙率（CT.PO）再现性的因素。 RMS％CV的范围为几何形状为0.2％-2.5％，BMD为0.6％-1.7％，小梁骨的0.7％-2.4％，皮质厚度为1.1％-1.3％，表现出优异的再现性。 CT.PO的RMS％CV的范围为11.0％-13.3％，比其他参数相对较高。内部间酯或间卫之间没有明显的差异。 CT.PO和受试者背景特征，运动伪影和皮质骨结构之间的百分比与皮质骨结构之间没有明显的相关性。第二代HR-PQCT的再现性在几何形状，BMD，小梁骨和皮质厚度方面具有优异的，在内特和间卫之间的性能之间没有明显的差异。与第一代HR-PQCT相比，细胞分枝骨的再现性得到改善。 CT.PO的再现性不足，需要改进，影响其重现性的因素尚不清楚。

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