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首页> 外文期刊>Journal of Controlled Release: Official Journal of the Controlled Release Society >Nanoparticle encapsulated core-shell hydrogel for on-site BMSCs delivery protects from iron overload and enhances functional recovery
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Nanoparticle encapsulated core-shell hydrogel for on-site BMSCs delivery protects from iron overload and enhances functional recovery

机译：纳米粒子包封核 - 壳水凝胶用于现场BMSCs的递送免受铁过载保护并增强功能恢复

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The local microenvironment may influence the success of stem cell therapy. Iron overload occurs in many hemorrhagic injuries due to hemolysis and hemoglobin degradation, which not only mediates local cell injury, but also induces damage to the transplanted cells. Here, an injectable nanoparticle encapsulated core-shell hydrogel was fabricated for simultaneous iron overload clearance and bone marrow mesenchymal stem cells (BMSCs) transplantation following intracerebral hemorrhage (ICH). The iron chelator-loaded low-molecular-weight keratin hydrogel with quick degradation property was selected as the outer shell to eliminate iron overload, and BMSCs implantation with high-molecular-weight keratin hydrogel was selected as the inner core. The epidermal growth factor and the basic fibroblast growth factor were entrapped within the poly (lactic-co-glycolic acid) (PLGA) nanoparticle, which was then encapsulated into the core hydrogel to support the BMSC growth and differentiation. The core-shell hydrogel can be easily formed by programmed injections, and the core-shell hydrogel displayed a strong protective effect against the toxicity of hemoglobin in cell experiments. Furthermore, more BMSCs survived in the core-shell hydrogel group in vivo as compared to that in the core hydrogel group and the vehicle group. Less iron deposition and ventricular enlargement, lower brain water content, and faster neurological recovery were also observed. The data demonstrated that this core-shell hydrogel is an effective strategy for promoting transplanted cell survival under the condition of an iron overload.
机译：局部微环境可能影响干细胞疗法的成功。由于溶血和血红蛋白降解导致的许多出血损伤发生铁过载，这不仅介导局部细胞损伤，而且还诱导移植细胞的损伤。这里，制备可注射纳米颗粒包封的核 - 壳水凝胶，用于同时进行铁过载间隙和骨髓间充质干细胞（BMSCs）移植后脑出血（ICH）。选择具有快速降解特性的铁螯合螯合螯合剂的低分子量角蛋白作为外壳，以消除铁过载，并选择具有高分子重量异咯酸水凝胶的BMSCs植入作为内芯。表皮生长因子和碱性成纤维细胞生长因子被捕获在聚（乳酸 - 共乙醇酸）（PLGA）纳米颗粒内，然后将其包封在核心水凝胶中以支持BMSC生长和分化。通过编程的注射可以容易地形成核 - 壳水凝胶，核心壳水凝胶对细胞实验中血红蛋白的毒性产生了强烈的保护作用。此外，与核心水凝胶基团和载体组中，更多的BMSC在体内的核心 - 壳水凝胶基团中存活。还观察到较少的铁沉积和心室扩大，降低脑含水量和更快的神经恢复。数据证明，该核 - 壳水凝胶是在铁过载条件下促进移植细胞存活的有效策略。

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