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首页> 外文期刊>Journal of Controlled Release: Official Journal of the Controlled Release Society >Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly (propylene sulfide) scaffolds loaded with poorly water-soluble drugs
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Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly (propylene sulfide) scaffolds loaded with poorly water-soluble drugs

机译：通过可注射的星形（乙二醇）-b-poly（丙烯酰硫醚）支架加速伤口愈合，用差水溶性药物负载

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摘要

Injectable hydrogel matrices take the shape of a wound cavity and serve as scaffold for tissue repair and regeneration. Yet these materials are generally hydrophilic, limiting the incorporation of poorly water soluble, hydrophobic drugs. Here we show this shortcoming is circumvented through a star-shaped amphiphilic block copolymer comprising poly(ethylene glycol) and poly (propylene sulfide). This star-shaped amphiphilic polymer self-assembles in an aqueous medium into a physically stable hydrogel and effectively dissolves hydrophobic molecules delivering them at therapeutic doses. The self assembled hydrogel is a robust three-dimensional scaffold in vivo effectively promoting cellular infiltration, reducing inflammation, and wound clsoure. When combined with a hydrophobic BRAF inhibitor that promotes paradoxical mitogen-activated protein kinase (MAPK) activation in keratinocytes and wound closure, our self assembled scaffold supported dermal wound closure at a reduced drug dosage compared to administering the drug in dimethyl sulfoxide (DMSO) without a polymeric matrix. This family of star-shaped amphiphilic polymers delivers poorly water soluble active agents at a fraction of generally required dosage for efficacy and supports three-dimensional cell growth at tissue wounds, showing great promise for novel uses of hydrophobic drugs in tissue repair applications.
机译：可注射水凝胶基质采用伤口腔的形状，用作组织修复和再生的支架。然而，这些材料通常是亲水的，限制了含水不良，疏水药物的掺入。在这里，我们显示出这种缺点通过包含聚（乙二醇）和聚（硫化丙酯）的星形两亲嵌段共聚物来规避。该星形两亲性聚合物在水性培养基中自组装成物理稳定的水凝胶，并有效地溶解在治疗剂量的疏水分子。自组装水凝胶是体内稳健的三维支架，有效地促进细胞浸润，还原炎症和伤口Clsoure。当与疏水性BRAF抑制剂组合时，促进角质形成细胞和伤口闭合促进矛盾的丝裂剂活化蛋白激酶（MAPK）活化，与在二甲基亚甲醚（DMSO）中施用药物的药物剂量减少的药物剂量，我们的自组装支架支撑了皮肤伤口闭合聚合物基质。这家星形的两亲性聚合物在一部分通常需要剂量的疗效中提供差的水溶性活性剂，并支持在组织伤口的三维细胞生长，表现出在组织修复应用中的新用途新用途的许多希望。

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  • 作者

    Zhu Suwei; Li Shuoran; Escuin-Ordinas Helena; Dimatteo Robert; Xi Weixian; Ribas Antoni; Segura Tatiana;

  • 作者单位

    Univ Calif Los Angeles Dept Chem &

    Biomol Engn 420 Westwood Plaza 5531 Boelter Hall Los Angeles CA 90095 USA;

    Univ Calif Los Angeles Dept Chem &

    Biomol Engn 420 Westwood Plaza 5531 Boelter Hall Los Angeles CA 90095 USA;

    Univ Calif Los Angeles Dept Med Div Hematol Oncol 420 Westwood Plaza 5531 Boelter Hall Los Angeles CA 90095 USA;

    Univ Calif Los Angeles Dept Chem &

    Biomol Engn 420 Westwood Plaza 5531 Boelter Hall Los Angeles CA 90095 USA;

    Univ Calif Los Angeles Dept Chem &

    Biomol Engn 420 Westwood Plaza 5531 Boelter Hall Los Angeles CA 90095 USA;

    Univ Calif Los Angeles Dept Med Div Hematol Oncol 420 Westwood Plaza 5531 Boelter Hall Los Angeles CA 90095 USA;

    Univ Calif Los Angeles Dept Chem &

    Biomol Engn 420 Westwood Plaza 5531 Boelter Hall Los Angeles CA 90095 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    Delivery scaffold; Hydrophobic drugs; Tissue repair;

    机译：递送脚手架;疏水药;组织修复;

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