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首页> 外文期刊>AIDS >Polymorphism in interleukin-7 receptor α gene is associated with faster CD4+ T-cell recovery after initiation of combination antiretroviral therapy
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Polymorphism in interleukin-7 receptor α gene is associated with faster CD4+ T-cell recovery after initiation of combination antiretroviral therapy

机译：联合抗逆转录病毒疗法启动后，白细胞介素7受体α基因的多态性与更快的CD4 + T细胞恢复有关

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OBJECTIVES:: To investigate single-nucleotide polymorphisms (SNPs) in the gene encoding interleukin-7 receptor α (IL7RA) as predictors for CD4 T-cell change after initiation of combination antiretroviral therapy (cART) in HIV-infected whites. DESIGN:: SNPs in IL7RA were determined in the Danish HIV Cohort Study. METHODS:: CD4 T-cell changes were estimated 6 months, 1, 2, and 5 years after initiation of cART in 1683 HIV-infected virally suppressed individuals. Five SNPs in IL7RA were examined as predictors for CD4 T-cell change in the first (0-6 months after initiation of cART) and second phase (>6 months after initiation of cART) of immune recovery. Univariable and multivariable analyses including age, sex, calendar period, CD4 nadir, and baseline CD4 T-cell count and viral load as covariates were performed. RESULTS:: Individuals carrying two T-alleles in rs6897932 had faster CD4 T-cell recovery compared with individuals carrying a C-allele in the first phase of immune recovery [mean CD4 T-cell change, cells/μL (95% confidence interval), in TT: 177 (151-203), CT: 131 (119-143), CC: 141 (132-151), P=0.018]. No isolated effect of rs6897932 on CD4 T-cell change was found in the second phase of immune recovery; however, the initial difference in CD4 T-cell recovery remained during 5 years. The effect was most pronounced in individuals above 40 years of age. CONCLUSION:: T-allele homozygosity in rs6897932 is a predictor for faster CD4 T-cell recovery after initiation of cART in HIV-infected whites, however, only in the first phase of immune recovery.
机译：目的：研究在感染艾滋病毒的白人中开始联合抗逆转录病毒疗法（cART）后，白介素7受体α（IL7RA）编码CD4 T细胞变化的预测因子的单核苷酸多态性（SNP）。设计：： IL7RA中的SNP在丹麦HIV队列研究中确定。方法：在1683年被HIV感染的病毒抑制个体中，cART启动后6个月，1、2和5年，估计CD4 T细胞变化。在免疫恢复的第一阶段（cART启动后0-6个月）和第二阶段（cART启动后> 6个月），检测了IL7RA中的五个SNPs作为CD4 T细胞变化的预测因子。进行单变量和多变量分析，包括年龄，性别，日历时间，CD4最低点和基线CD4 T细胞计数以及病毒载量作为协变量。结果：与在免疫恢复的第一阶段携带C等位基因的个体相比，在rs6897932中携带2个T等位基因的个体具有更快的CD4 T细胞恢复[平均CD4 T细胞变化，细胞/μL（95％置信区间） ，在TT：177（151-203），CT：131（119-143），CC：141（132-151），P = 0.018]。在免疫恢复的第二阶段，未发现rs6897932对CD4 T细胞改变的单独作用;但是，CD4 T细胞恢复的最初差异在5年内仍然存在。这种作用在40岁以上的个体中最为明显。结论：rs6897932中的T等位基因纯合性是在感染HIV的白人中启动cART后CD4 T细胞恢复更快的预测因子，但是，仅在免疫恢复的第一阶段。

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