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首页> 外文期刊>Journal of Cytology >Cytomorphological Differences between Liquid-Based Cytology and Conventional Smears in Fine-Needle Aspirates of Thyroid Lesions
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Cytomorphological Differences between Liquid-Based Cytology and Conventional Smears in Fine-Needle Aspirates of Thyroid Lesions

机译：甲状腺病变细针吸气中液体基细胞学和常规涂片之间的细胞骨髓差异

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Background: Liquid-based cytology (LBC) is becoming an independent processing modality for cytology specimens. Decreased obscuration, single-slide examination, lesser screening time, and potential application of ancillary techniques are the various advantages it offers. Aim: To study and compare the cytological features of fine-needle aspirates from thyroid swellings on LBC with conventional smears (CS). Materials and Methods: Fine-needle aspiration was performed on 150 patients with thyroid nodule. The aspirate was first used to prepare a minimum of two CS and the remaining aspirate was used to prepare one SurePath smear. The final diagnosis was given according to the Bethesda system for reporting thyroid cytopathology (2007). Cytomorphological parameters were semi-quantitatively scored. Pearson's Chi-square test was used and P value was calculated. A P value 0.05 was considered significant. Cytohistological correlation was done wherever possible. Results: LBC showed higher nondiagnostic rate than CS. Significant cytomorphological differences on LBC included: (i) higher frequency of single, naked nuclei; (ii) lesser nuclear and cytoplasmic details; (iii) decreased colloid which appeared differently (as napkin fold and dense droplet); (iv) increased cyst macrophages; and (v) decreased obscuration by blood. Conclusion: LBC can supplement CS but cannot replace it.
机译：背景：基于液体的细胞学（LBC）正在成为细胞学样本的独立处理模型。遮挡，单滑石检查，较小的筛选时间，以及辅助技术的潜在应用是其所提供的各种优势。目的：用常规涂片（CS）研究和比较甲状腺溶胀的细针吸气的细胞学特征。材料和方法：在150例甲状腺结节患者上进行细针吸入。首先使用吸气物用于制备至少两个Cs，并且使用剩余的吸气剂制备一个禁止污迹。根据贝塞斯达系统给出最终诊断，用于报告甲状腺细胞病变（2007）。细胞形态参数分别定量得分。使用Pearson的Chi-Square测试并计算P值。 p值＆ 0.05被认为是显着的。尽可能完成细胞学相关性。结果：LBC表现出比CS更高的非炎症率。 LBC的显着细胞骨髓差异包括：（i）单裸体核的较高频率; （ii）较小的核和细胞质细节; （iii）减少胶体，其出现不同（作为餐巾折叠和致密液滴）; （iv）增加囊肿巨噬细胞; （v）通过血液降低遮挡。结论：LBC可以补充CS但不能取代它。

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