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首页> 外文期刊>Journal of diabetes research. >Serum 25-Hydroxyvitamin D3 Levels Are Associated with Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaque in Type 2 Diabetic Patients
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Serum 25-Hydroxyvitamin D3 Levels Are Associated with Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaque in Type 2 Diabetic Patients

机译：血清25-羟基维生素D3水平与2型糖尿病患者的颈动脉内膜介质厚度和颈动脉粥样硬化斑块有关

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Objective. To investigate the relationship between serum 25-hydroxyvitamin D3 [25(OH)D3] levels and carotid intima-media thickness (IMT) as well as carotid atherosclerotic plaque in patients with type 2 diabetes mellitus (T2DM). Methods. 314 patients with T2DM were enrolled in this study. The clinical data and laboratory examinations of subjects were recorded, such as serum 25(OH)D3, hemoglobin A1c (HbA1c), serum lipids, fasting blood glucose (FBG), and other biochemical parameters. Color Doppler ultrasound was used to measure carotid IMT and carotid atherosclerotic plaques. Patients were divided into four quartile groups according to the serum 25(OH)D3 levels from low to high: group Q1 similar to group Q4. Results. From group Q1 to group Q4, carotid IMT and the incidence of plaque were gradually reduced. Serum 25(OH) D3 levels were lower in the plaque group compared with the nonplaque group (P < 0 01). Serum 25(OH)D3 levels were negatively correlated with the carotid IMT (r = -0.4, P < 0.01). Multiple linear stepwise regression analysis showed that serum 25(OH) D3 was independently associated with carotid IMT (beta = -0.009, P < 0.01). Logistic regression analysis showed that serum 25(OH)D3 levels were independently associated with the presence of carotid plaque in T2DM (OR = 0.95; 95% CI: 0.92 similar to 0.98, P = 0.004). Conclusions. Low vitamin D status may contribute to the incidence of carotid atherosclerosis in type 2 diabetic patients.
机译：客观的。研究患有2型糖尿病（T2DM）的血清25-羟基乙多蛋白D3 [25（OH）D3]水平和颈动脉粥样硬化斑块的颈动脉粥样硬化斑块之间的关系。方法。 314例患有T2DM的患者参加本研究。记录受试者的临床资料和实验室检查，例如血清25（OH）D3，血红蛋白A1C（HBA1C），血清脂质，空腹血糖（FBG）和其他生化参数。颜色多普勒超声用于测量颈动脉IMT和颈动脉粥样硬化斑块。根据低至高分子的血清25（OH）D3水平，患者分为四个四分位数：基团Q1类似于Q4。结果。从组Q1到第Q4组，颈动脉IMT和斑块的发病率逐渐减少。与非平面基团相比，斑块组中血清25（OH）D3水平较低（P <0 01）。血清25（OH）D3水平与颈动脉IMT（R = -0.4，P <0.01）负相关。多个线性逐步回归分析显示，血清25（OH）D3与颈动脉IMT（β= -0.009，P <0.01）独立相关。逻辑回归分析表明，血清25（OH）D3水平与T2DM中的颈动脉斑块（或= 0.95; 95％CI：0.92类似于0.98，P = 0.004），独立相关。结论。低维生素D状态可能有助于2型糖尿病患者的颈动脉粥样硬化发生率。

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