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首页> 外文期刊>Journal of dietary supplements >Abrogation of Hepatic Damage Induced by Anticancer Drug Methotrexate by Zobo [Hibiscus sabdariffa extract) Supplementation via Targeting Oxidative Hepatotoxicity in Rati
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Abrogation of Hepatic Damage Induced by Anticancer Drug Methotrexate by Zobo [Hibiscus sabdariffa extract) Supplementation via Targeting Oxidative Hepatotoxicity in Rati

机译：通过Zoboγ甲氨蝶呤通过靶向氧化肝毒性诱导抗癌药物甲氨蝶呤诱导的肝损伤

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Clinical use of methotrexate (MTX) in cancer chemotherapy is limited due to its side effects, notably associated with increased oxidative stress and hepatotoxicity. Zobo is an aqueous extract of Hibiscus sab-dariffa known to contain natural antioxidants. The present study investigated the hepatoprotective effect of zobo drink (ZD) on MTX-induced oxidative stress and hepatotoxicity in rats. Rats randomized to control group received distilled water orally; MTX group received intraperitoneal (ip) injection of MTX (20 mg/kg) on day 11; ZD + MTX group was administered ZD (10 ml/kg) for 14 days and was injected with MTX on day 11. Three days after MTX injection, enzyme markers of liver injury, protein profile, and bilirubin were assessed in serum. Hepaticactivities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and level of lipid peroxidation were estimated. Histopathological changes were carried out on the liver tissue. MTX induced prominent oxidative hepatotoxicity demonstrated by significant (p < .01) increases in serum liver enzymes and bilirubin, while protein profile was markedly reduced (p < .05). Hepatic activities of SOD, CAT, and GPx considerably decreased, whereas lipid peroxidation increased significantly inthe MTX group compared to control. By contrast, ZD administration attenuated and restored the markers of liver injury, hepatic antioxidant enzymes, and lipid peroxidation near to control, while histopathological alterations were ameliorated compared tothe MTX group. ZD affords superior protection against MTX-induced oxidative hepatotoxicity via improvement in antioxidant defense systems in rats. ZD could be a potent natural product against hepatotoxicity associated with MTX chemotherapy in cancer patients.
机译：由于其副作用，甲氨蝶呤（MTX）在癌症化疗中的临床应用受到限制，显着与增加的氧化应激和肝毒性相关。 ZOBO是已知含有天然抗氧化剂的芙蓉SAB-DARIFFA的水性提取物。本研究研究了ZOBO饮料（ZD）对大鼠MTX诱导的氧化应激和肝毒性的肝保护作用。随机化对对照组的大鼠口服蒸馏水; MTX组在第11天接受腹膜内（IP）注射MTX（20mg / kg）; Zd + MTX基团施用ZD（10ml / kg）14天，并在第11天注射MTX。在MTX注射后三天，在血清中评估肝损伤，蛋白质分布和胆红素的酶标记。估计超氧化物歧化酶（SOD），过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPX）和脂质过氧化水平的肝动力。在肝脏组织上进行组织病理学变化。 MTX诱导突出的氧化肝毒性，显着（p <.01）增加血清肝酶和胆红素，而蛋白质曲线明显减少（p <.05）。与对照相比，SOD，猫和GPX的肝脏活性显着降低，而脂质过氧化显着增加了MTX组。相比之下，ZD给药衰减并恢复了肝损伤，肝抗氧化酶和脂质过氧化的标志物，靠近对照，而组织病理学改变得到了抑制MTX基团。 Zd通过改善大鼠抗氧化剂防御系统，通过改善抗氧化剂防御系统，提供优异的保护。 ZD可以是患有癌症患者MTX化疗相关的肝毒性的有效天然产物。

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