Broad and persistent Gag-specific CD8(+) T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection

Radebe Mopo; Gounder Kamini; Mokgoro Mammekwa; Ndhlovu Zaza M.; Mncube Zenele; Mkhize Lungile; van der Stok Mary; Jaggernath Manjeetha; Walker Bruce D.; Ndungu Thumbi

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Broad and persistent Gag-specific CD8(+) T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection

机译：广泛而持久的Gag特异性CD8（+）T细胞反应与病毒控制有关，但在原发性HIV-1感染期间很少推动病毒逃逸

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Objective: We characterized protein-specific CD8(+) T-cell immunodominance patterns during the first year of HIV-1 infection, and their impact on viral evolution and immune control.

机译：目的：我们表征了HIV-1感染的第一年中蛋白质特异性CD8（+）T细胞的免疫支配模式，及其对病毒进化和免疫控制的影响。

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来源
《AIDS》 |2015年第1期|共11页
作者
Radebe Mopo; Gounder Kamini; Mokgoro Mammekwa; Ndhlovu Zaza M.; Mncube Zenele; Mkhize Lungile; van der Stok Mary; Jaggernath Manjeetha; Walker Bruce D.; Ndungu Thumbi;
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正文语种 eng
中图分类传染病;
关键词
acute HIV-1 infection; CD8(+) T cells; central CD8(+) T-cell memory responses; gag-specific responses; immune escape; persistent CD8(+) T-cell responses;

机译：急性HIV-1感染;CD8（+）T细胞;中央CD8（+）T细胞记忆反应;gag特异性反应;免疫逃逸;持续性CD8（+）T细胞反应;

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1. Broad and persistent Gag-specific CD8(+) T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection [J] . Radebe Mopo, Gounder Kamini, Mokgoro Mammekwa, AIDS . 2015,第1期

机译：广泛而持久的Gag特异性CD8（+）T细胞反应与病毒控制有关，但在原发性HIV-1感染期间很少推动病毒逃逸
2. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. [J] . Oxenius A, Price DA, Trkola A, The Journal of Infectious Diseases . 2004,第4期

机译：早期HIV-1感染中病毒控制力的丧失与CD8 + T细胞反应的顺序逃逸以及HIV-1特异性CD4 +和CD8 + T细胞频率的降低暂时相关。
3. The roles of HIV-1 specific CD8+ T cell responses and HLA class I alleles on viral control and viral escape in HIV-1 infected Thai individuals [J] . S Buranapraditkun, U Hempel, WH Hildebrand, Retrovirology . 2012,第S2期

机译：HIV-1特异性CD8 + T细胞应答和HLA类I等位值对病毒对照和病毒逃逸的影响，HIV-1受感染的泰国个人
4. THE ADVANTAGE OF PERSISTENT VIRAL INFECTIONS (VIRAL ACCOMMODATION) IN CRUSTACEANS AND OTHER ARTHROPODS [C] . T.W. Flegel International Conference of the European Aquaculture Society . 2004

机译：甲壳类动物和其他节肢动物中持续性病毒感染（病毒型住院）的优势
5. Humoral and cellular immune responses in RNA viral infections: Immunogenicity of HIV-1, HCV and SARS-CoV candidate vaccines in animal models. [D] . Azizi, Ali. 2006

机译：RNA病毒感染中的体液和细胞免疫应答：HIV-1，HCV和SARS-CoV候选疫苗在动物模型中的免疫原性。
6. Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection [O] . Mopo Radebe, Kamini Gounder, Mammekwa Mokgoro, -1

机译：广泛而持久的Gag特异性CD8 + T细胞反应与病毒控制有关但在原发HIV-1感染期间很少推动病毒逃逸
7. Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection [O] . Radebe , M., Gounder , K., Mokgoro, M., 2015

机译：广泛和持久的Gag特异性CD8 + T细胞反应与病毒控制有关，很少在原发HIV-1感染期间驱动病毒逃逸

Broad and persistent Gag-specific CD8(+) T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection

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