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首页> 外文期刊>Journal of digestive diseases >Endoscopic needle‐knife treatment for symptomatic esophageal Zenker’s diverticulum: A meta‐analysis and systematic review
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Endoscopic needle‐knife treatment for symptomatic esophageal Zenker’s diverticulum: A meta‐analysis and systematic review

机译：对症状食管Zenker的憩室的内窥镜针刀治疗：META分析和系统审查

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OBJECTIVE The aim of this study was to assess the efficacy and safety following endoscopic management of Zenker’s diverticulum (ZD) using a needle‐knife technique. METHODS A systematic search of PubMed, Embase and Cochrane library databases was performed. All original studies reporting efficacy and safety of needle‐knife technique for treatment of ZD were included. Pooled event rates across studies were expressed with summative statistics. Main outcomes, such as rates of immediate symptomatic response (ISR), adverse events and recurrence, were extracted, pooled and analyzed. Heterogeneity among studies was assessed using the R statistic. The random effects model was used and results were expressed with forest plots and summative statistics. RESULTS Thirteen studies included 589 patients were enrolled. Pooled event rates for ISR, overall complication, bleeding and perforation were 88% (95% confidence interval [CI] 79–94%), 13% (95% CI 8–22%), 5% (95% CI 3–10%) and 7% (95% CI 4–12%), respectively. The pooled data demonstrated an overall recurrence rate of 14% (95% CI 9–21%). Diverticulum size of at least 4?cm and less than 4?cm demonstrated pooled adverse event rates of 17% (95% CI 10–27%) and 7% (95% CI 2–18%), respectively. When using diverticuloscope as an accessory, pooled ISR and adverse events rates were 84% (95% CI 58–95%) and 10% (95% CI 3–26%), respectively. CONCLUSION Flexible endoscopic procedures using needle‐knife offers a relatively safe and effective treatment of symptomatic ZD, especially for ZD of 4?cm in diameter.
机译：目的本研究的目的是使用针刀技术评估Zenker憩室（ZD）内窥镜管理后的疗效和安全性。方法执行PubMed，Embase和Cochrane库数据库的系统搜索。包括所有原始研究报告针对ZD治疗针刀技术的疗效和安全性。跨学习的汇集活动率以总结统计表达。提取，汇总和分析，提取主要结果，例如直接对症反应（ISR），不良事件和复发的速率。使用R统计评估研究中的异质性。使用随机效果模型，结果表达了森林图和总结统计。结果13项研究包括589名患者。 ISR的汇集事件率，总体并发症，出血和穿孔是88％（95％置信区间[CI] 79-94％），13％（95％CI 8-22％），5％（95％CI 3-10 ％）分别为7％（95％CI 4-12％）。汇总数据表明总复发率为14％（95％CI 9-21％）。憩室尺寸至少为4Ω·cm，小于4厘米，分别证明汇集不良事件率为17％（95％CI 10-27％）和7％（95％CI 2-18％）。当使用憩室镜作为附件时，合并的ISR和不良事件率分别为84％（95％CI 58-95％）和10％（95％CI 3-26％）。结论采用针脚柔性内窥镜手术，提供对症状Zd的相对安全和有效的治疗，特别是对于直径为4Ω·厘米的Zd。

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