...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cranio-Maxillofacial Surgery >A new multilayered membrane for tissue engineering of oral hard- and soft tissue by means of melt electrospinning writing and film casting - An in vitro study
【24h】

A new multilayered membrane for tissue engineering of oral hard- and soft tissue by means of melt electrospinning writing and film casting - An in vitro study

机译：一种新的多层膜，通过熔体静电纺装和薄膜铸造口腔软组织组织工程 - 体外研究

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Membranes that form a mechanical barrier not only for cells but also for the bacterial flora of the oral cavity may be helpful in infection-free wound healing for guided tissue regeneration (GTR) applications in the field of oral- and maxillofacial surgery. Controlled wound healing without interference from bacterial contamination appears to be achievable in combination with surface scaffolds for bone- and soft tissue regeneration. As this has not yet been realized, we developed multilayered membranes in this study consisting of specific surface scaffolds for bone-and mucosal regeneration as well as bacteria-tight core membranes. These membranes were evaluated in terms of cell growth of osteoblast- (MG63), keratinocyte-(HaCaT), and fibroblast (L929) cell lines. Scaffolds were fabricated via melt electrospinning writing (MEW), while the core membrane was produced via film casting. All constructs were made of medical-grade poly(epsilon-caprolactone) (PCL). The bacteria-tightness was tested via a bacterial transmigration-assay. PCL scaffolds and core membranes alone demonstrated good cytocompatibility for all cell lines, which was even enhanced by fusing both components together. The core membrane displayed complete bacteria-tightness over two weeks. These bacteria-tight, individually-designed membranes from medical-grade PCL represent a high-potential, clinically oriented method of GTR in the field of oral- and maxillofacial surgery. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
机译：形成机械屏障的膜不仅适用于细胞，而且对于口腔的细菌植物群可能有助于在口腔和颌面外科领域的引导组织再生（GTR）应用的无感染伤口愈合。没有从细菌污染的干扰干扰的受控伤口愈合似乎与用于骨骼和软组织再生的表面支架组合可以实现。正如尚未实现的那样，我们在该研究中开发了多层膜，其由特定表面支架组成，用于骨和粘膜再生以及细菌密封的核心膜。根据骨灌注（Mg63），角质形成细胞 - （HACAT）和成纤维细胞（L929）细胞系的细胞生长来评估这些膜。通过熔融静电纺丝书写（MEW）制造支架，而芯膜通过薄膜铸造制造。所有构建体均由医用级聚（ε-己内酯）（PCL）制成。通过细菌迁移测定测试细菌性紧张。仅PCL支架和核心膜对所有细胞系表现出了良好的细胞组合，其甚至通过将两个组分融合在一起甚至增强。核心膜在两周内显示出完全的细菌紧张。来自医疗级PCL的这些细菌密封，独立设计的膜代表了口腔和颌面外科领域的高潜力，临床导向方法。 （c）2019年欧洲Cranio-Maxillo-Facial手术协会。 elsevier有限公司出版。保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号