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Botulinum Toxin in the Long-Term Treatment of Refractory Raynaud's Phenomenon

机译:肉毒杆菌毒素在长期治疗难治性雷诺的现象

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摘要

Raynaud's phenomenon is an exaggerated physiological response of blood vessels in the distal extremities to emotional stress and cold. It can be idiopathic or secondary to a connective tissue disorder, such as scleroderma or systemic lupus erythematosus. Treatment for Raynaud's phenomenon consists primarily of lifestyle modifications; if unsuccessful, pharmacotherapy with dihydropyridine calcium channel blockers can be added. Botulinum toxin (BTX-A) is a neurotoxic protein produced by Clostridium botulinum spores. While most widely known for its cosmetic use, BTX-A has many therapeutic utilities due to its ability to inhibit multiple neurotransmitters. In this report, we present a patient with Raynaud's phenomenon refractory to standard therapies whose symptoms resolved after treatment with BTX-A. Follow-up with the patient after one and five years showed no relapse or recurrence of symptoms.
机译:Raynaud的现象是对情绪压力和寒冷的远端四肢血管的夸张生理反应。 它可以是特发性的或继发于结缔组织障碍,例如硬皮病或系统性红斑狼疮。 Raynaud现象的治疗主要由生活方式修改组成; 如果不成功,可以添加药物治疗二氢吡啶钙通道阻滞剂。 肉毒杆菌毒素(BTX-A)是由梭菌骨髓孢子产生的神经毒性蛋白质。 虽然最广为人知的化妆品使用,但BTX-A由于其抑制多种神经递质的能力而具有许多治疗性公用设施。 在本报告中,我们展示了raynaud的现象对标准疗法难以进行的标准疗法,其症状在用BTX-a治疗后解决。 在一到五年后与患者随访显示症状没有复发或复发。

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