Randomized, Placebo- and Active-Controlled Crossover Study of the Safety and Efficacy of THVD-102, a Fixed-dose Combination of Oxybutynin and Pilocarpine, in Subjects With Primary Focal Hyperhidrosis

Pariser David M.; Krishnaraja Janakan; Tremblay Thomas M.; Rubison R. Michael; Love Ted W.; McGraw Benjamin E. III

首页> 外文期刊>Journal of drugs in dermatology: JDD >Randomized, Placebo- and Active-Controlled Crossover Study of the Safety and Efficacy of THVD-102, a Fixed-dose Combination of Oxybutynin and Pilocarpine, in Subjects With Primary Focal Hyperhidrosis

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Randomized, Placebo- and Active-Controlled Crossover Study of the Safety and Efficacy of THVD-102, a Fixed-dose Combination of Oxybutynin and Pilocarpine, in Subjects With Primary Focal Hyperhidrosis

机译：随机，安慰剂和主动控制的交叉研究THVD-102的安全性和有效性，oxybutynin和Pilocarpine的固定剂量组合，主局部局灶性患者

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Background: While muscarinic antagonists (anticholinergics) have shown efficacy in treating primary focal hyperhidrosis (PFH), side effects - most commonly dry mouth - are intolerable for most patients. THVD-102, a fixed-dose combination product has been developed combining oxybutynin, a muscarinic antagonist, and pilocarpine, a muscarinic agonist. The pilocarpine is at a dose level and release profile optimized to correct salivary flow impaired by oxybutynin yet not interfere with the therapeutic muscarinic antagonist effect of oxybutynin upon the sweat glands.

机译：背景：虽然毒蕈碱拮抗剂（抗胆碱能器）在治疗初级局灶性患有（PFH），副作用 - 最常见的患者中，但对于大多数患者来说，副作用是较常见的患者的疗效。 THVD-102，已经开发了一种固定剂量组合产物，组合oxybutynin，毒蕈碱拮抗剂和毒蕈碱，毒蕈碱激动剂。汲取甘油在剂量水平和释放曲线上，优化以纠正奥昔宁蛋白损害的唾液流动且不会干扰奥昔林蛋白在汗腺上的治疗毒蕈碱拮抗作用。

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《Journal of drugs in dermatology: JDD》 |2017年第2期|共6页
作者
Pariser David M.; Krishnaraja Janakan; Tremblay Thomas M.; Rubison R. Michael; Love Ted W.; McGraw Benjamin E. III;
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作者单位

Eastern Virginia Med Sch Norfolk VA 23501 USA;

Linear Clin Res Perth WA Australia;

TheraVida Inc San Mateo CA USA;

Flint Hills Consulting LLC Lake Forest IL USA;

TheraVida Inc San Mateo CA USA;

TheraVida Inc San Mateo CA USA;

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正文语种 eng
中图分类药学;
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Randomized, Placebo- and Active-Controlled Crossover Study of the Safety and Efficacy of THVD-102, a Fixed-dose Combination of Oxybutynin and Pilocarpine, in Subjects With Primary Focal Hyperhidrosis

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