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首页> 外文期刊>Journal of drugs in dermatology: JDD >Regression Analysis of Local Skin Reactions to Predict Clearance of Actinic Keratosis on the Face in Patients Treated With Ingenol Mebutate Gel: Experience from Randomized Controlled Trials
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Regression Analysis of Local Skin Reactions to Predict Clearance of Actinic Keratosis on the Face in Patients Treated With Ingenol Mebutate Gel: Experience from Randomized Controlled Trials

机译：局部皮肤反应的回归分析，以预测ingenol浆凝胶凝胶治疗患者脸部脸部脸部的清除：随机对照试验的经验

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摘要

Ingenol mebutate gel, a topical field treatment for actinic keratosis (AK), elicits inflammatory application-site reactions in most patients. This analysis explored the relationship between the intensity of local skin reactions (LSRs) and AK clearance, measured by the reduction in AK count from baseline in 218 patients who were treated for AK on the face in the pivotal Phase 3 studies. The analysis modeled the AK count at week 8, adjusted for baseline count, with the composite LSR score at 1 day after the last treatment application for each patient as a predictor to estimate the mean and 90% prediction interval for the percent reduction in AK count. The predicted mean percent reduction in AK count was higher in patients with higher composite LSR scores. Lower composite scores demonstrated a variable, less predictive percentage reduction in efficacy. Therefore, a large inflammatory reaction from ingenol mebutate gives a more reliable prognosis for improved AK clearance.
机译：Ingenol Meufutate Gel，一种局部野生菌（AK）的局部处理，在大多数患者中引发炎症的应用部位反应。 该分析探讨了局部皮肤反应（LSRS）和AK间隙的强度之间的关系，通过在枢轴第3研究中对AK进行AK的218名患者的AK计数降低来测量。 在第8周的分析中，调整为基线计数的AK计数，在最后一次治疗申请后1天的复合LSR分数作为预测器，以估计AK计数减少百分比的平均值和90％的预测间隔 。 复合LSR评分较高患者的AK计数降低的预测平均百分比较高。 较低的综合评分证明了功效降低的可变性，更少的预测百分比降低。 因此，来自ingenol浆果的大炎症反应为改善的AK间隙提供了更可靠的预后。

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