Understanding the Role of Photolyases: Photoprotection and Beyond

Bhatia Neal; Berman Brian; Ceilley Roger I.; Kircik Leon H.

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Understanding the Role of Photolyases: Photoprotection and Beyond

机译：了解光聚酯的作用：光保护及超越

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The limitations of photoprotection modalities have been the inability to arrest the progression of photodamage. Chemoprevention strategies involving a sunscreen has been incomplete because of the need to induce sustained repair of mutations and slow carcinogenesis. Photolyases, or photoreactivation enzymes, serve the role of repairing mutations and damage to DNA induced by ultraviolet (UV) radiation and therefore influence the initiation phases of carcinogenesis. As these enzymes are absent in humans, exogenous forms have been manufactured and are now utilized in topical agents to supplement and augment the innate repair mechanisms that are mostly inefficient.

机译：光保护模型的局限性是无法抑制光电模脉的进展。涉及防晒霜的化学普化策略是不完整的，因为需要诱导持续修复突变和慢性致癌作用。光聚光酶或光反对子酶，用于修复紫外（UV）辐射诱导的DNA的修复和损伤的作用，从而影响致癌发生的引发相。随着这些酶在人体中不存在，已经制造了外源形式，现在用于局部试剂，以补充和增强主要是低效的先天修复机制。

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《Journal of drugs in dermatology: JDD》 |2017年第5suppla期|共6页
作者
Bhatia Neal; Berman Brian; Ceilley Roger I.; Kircik Leon H.;
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作者单位

Therapeut Clin Res San Diego CA 92123 USA;

Univ Miami Miller Sch Med Miami FL 33136 USA;

Dermatol PC W Des Moines IA USA;

Icahn Sch Med Mt Sinai New York NY 10029 USA;

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正文语种 eng
中图分类药学;
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1. Understanding the Role of Photolyases: Photoprotection and Beyond [J] . Bhatia Neal, Berman Brian, Ceilley Roger I., Journal of drugs in dermatology: JDD . 2017,第5Suppla期

机译：了解光聚酯的作用：光保护及超越
2. Energetics of Radical Formation in Eumelanin Building Blocks: Implications for Understanding Photoprotection Mechanisms in Eumelanin [J] . Agapito Filipe, Cabral Benedito J. Costa The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory . 2016,第50期

机译：Eumelanin构件中自由基形成的能量学：对理解Eumelanin中的光保护机制的启示。
3. Photoprotective Role of Photolyase-Interacting RAD23 and Its Pleiotropic Effect on the Insect-Pathogenic Fungus Beauveria bassiana [J] . Ding-Yi Wang, Ya-Ni Mou, Sen-Miao Tong, Applied Microbiology . 2020,第11期

机译：光化酶相互作用的RAD23对昆虫致病真菌Beauveria Bassiana的光保护作用及其抗性效应
4. THE ROLE OF CHLOROPHYLL B IN THE PHOTOPROTECTION OF PHOTOSYSTEM I AND II USING CHLOROPHYLL B LESS MUTANTS [C] . Eun Sang Yoo, Jin Hong Kim, Min-Hyuk Oh, International Congress of Photosynthesis . 2005

机译：叶绿素B在光保护中的作用I和II使用叶绿素B较少的突变体
5. Green and non-green fluorescing forms of the Caribbean coral Montastrea faveolata (Ellis and Solander, 1786), and their roles in photoprotection. [D] . McPhee, Lena Kristina. 2002

机译：加勒比珊瑚Montastrea faveolata的绿色和非绿色荧光形式（Ellis and Solander，1786），及其在光保护中的作用。
6. Photoprotective Role of Photolyase-Interacting RAD23 and Its Pleiotropic Effect on the Insect-Pathogenic Fungus Beauveria bassiana [O] . Ding-Yi Wang, Ya-Ni Mou, Sen-Miao Tong, 2020

机译：光化酶相互作用的RAD23对昆虫病原真菌嗜睡虫害的光保护作用及其抗性效应
7. Understanding and predicting a complex behavior using n-of-1 methods: Photoprotection in xeroderma pigmentosum. [O] . Kirby Sainsbury, Rute Vieira, Jessica Walburn, 2018

机译：使用N-of-1方法理解和预测复杂的行为：Xeroderma Pigmentosum中的光保护。

Understanding the Role of Photolyases: Photoprotection and Beyond

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