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Recurrent Herpes Labialis in Adults: New Tricks for an Old Dog

机译:在成人的复发性疱疹Labialis:一只老狗的新技巧

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Herpes labialis remains a common worldwide affliction. Recent advances in understanding the basic pathogenesis have led to new therapeutic intervention, both on-label and off-label. Aside from reducing the duration and symptomatology of acute outbreaks, another goal of treatment is to decrease the frequency of future episodes. Oral and topical acyclovir and its analogues are the mainstay of both chronic suppressive and episodic therapy. A new muco-adhesive formulation of acyclovir provides a decrease in outbreaks, probably due to a diminution of herpesvirus load in all reservoir sites. Acyclovir-resistant strains are rare in immunocompetent hosts; parenteral foscarnet and cidofovir are administered in this situation. Parenteral acyclovir is the drug of choice for eczema herpeticum, which may begin as herpes labialis in an atopic dermatitis patient. Thermotherapy may be beneficial, and a certified device to deliver heat is available outside the United States.
机译:疱疹Labialis仍然是全世界的共同痛苦。 理解碱性发病机制的最新进展导致了新的治疗干预,既标签和非标签。 除了降低急性爆发的持续时间和症状学,另一种治疗目标是降低未来发作的频率。 口腔和局部Acyclovir及其类似物是慢性抑制和显口疗法的支柱。 Acyclovir的一种新的粘液粘合剂制剂可降低爆发,可能是由于所有储层位点中的Herpesvirus负荷的减少。 免疫活性宿主中的耐菌毒性菌株罕见; 在这种情况下给予肠胃外弗斯科网络和Cidofovir。 肠胃外acyclovir是湿疹的首选药物,其可以在特应性皮炎患者中开始作为疱疹疱疹。 热疗可能是有益的,并且在美国以外提供热量的经过认证装置。

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