Update on the Systemic Risks of Superpotent Topical Steroids

Nakamura Mio; Abrouk Michael; Zhu Henry; Farahnik Benjamin; Koo John; Bhutani Tina

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Update on the Systemic Risks of Superpotent Topical Steroids

机译：超能级局部类固醇的系统风险更新

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Introduction: The potential for systemic effects due to percutaneous absorption of superpotent topical steroids has been a longstanding concern. The Food and Drug Administration currently recommends limiting the use of superpotent topical steroids to 50g per week for 2 or 4 consecutive weeks depending on the formulation, which is mostly based on the exact duration with which phase 3 clinical trials were allowed to be conducted per the FDA. This article reviews all published clinical incidence of adrenal adverse effects in the medical literature, specifically Cushing's syndrome (CS) and pathologic adrenal suppression (PAAS), to try to ascertain a more realistic limit for the safe use of superpotent topical steroids as it pertains to its potential systemic effects.

机译：介绍：由于超便利局部类固醇经皮吸收导致的全身效应的潜力是一种长期关注的问题。食品和药物管理局目前建议将超级局部类固醇限制在每周2或4周每周使用，这取决于制剂，这主要是基于允许每阶段3临床试验的确切持续时间来进行 FDA。本文摘要各种公布的肾上腺副作用在医学文献中，特别是缓冲的综合征（CS）和病理肾上腺抑制（PAAS），以确定更现实的限制，安全使用超级局部类固醇，因为它涉及它潜在的全身效应。

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来源
《Journal of drugs in dermatology: JDD》 |2017年第7期|共6页
作者
Nakamura Mio; Abrouk Michael; Zhu Henry; Farahnik Benjamin; Koo John; Bhutani Tina;
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作者单位

Univ Calif San Francisco Dept Dermatol Psoriasis &

Skin Treatment Ctr San Francisco CA 94143 USA;

Univ Calif Irvine Sch Med Irvine CA 92717 USA;

Univ Southern Calif Keck Sch Med Los Angeles CA USA;

Univ Vermont Coll Med Burlington VT USA;

Univ Calif San Francisco Dept Dermatol Psoriasis &

Skin Treatment Ctr San Francisco CA 94143 USA;

Univ Calif San Francisco Dept Dermatol Psoriasis &

Skin Treatment Ctr San Francisco CA 94143 USA;

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正文语种 eng
中图分类药学;
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1. Update on the Systemic Risks of Superpotent Topical Steroids [J] . Nakamura Mio, Abrouk Michael, Zhu Henry, Journal of drugs in dermatology: JDD . 2017,第7期

机译：超能级局部类固醇的系统风险更新
2. Combined treatment with low-dose methotrexate and initial short-term superpotent topical steroids in bullous pemphigoid: an open, multicentre, retrospective study. [J] . Du Thanh A, Merlet S, Maillard H, British Journal of Dermatology . 2011,第6期

机译：大剂量天疱疮中低剂量甲氨蝶呤和短期短期超效局部类固醇联合治疗：一项开放，多中心，回顾性研究。
3. Combined treatment with low-dose methotrexate and initial short-term superpotent topical steroids in bullous pemphigoid: an open, multicentre, retrospective study [J] . A. Du-Thanh, S. Merlet, H. Maillard, British Journal of Dermatology . 2011,第6期

机译：大剂量天疱疮小剂量甲氨蝶呤联合短期短期超效局部类固醇的联合治疗：开放，多中心，回顾性研究
4. I have decided to treat my RAO case with systemic steroids: should I screen it for laminitis risk? [C] . Nicola Menzies-Gow British Equine Veterinary Association Congress . 2014

机译：我决定用全身类固醇治疗我的RAO病例：如果我筛选它的层层风险？
5. Use of Topical Non-steroidal Anti-inflammatory Drugs to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions [D] . Alshaneqiti, Ishraq 2019

机译：使用非甾体类抗炎局部用药减轻口腔扁平苔藓和口腔苔藓样病变的疼痛
6. The influence of topical non-steroidal anti-inflammatory drugs on the intraocular pressure lowering effect of topical prostaglandin analogues—A systemic review and meta-analysis [O] . Kang-Jung Lo, Yu-Chieh Ko, De-Kuang Hwang, 2020

机译：局部非甾体抗炎药对局部前列腺素类似物的眼压降低效应 - 一种全身评测及荟萃分析
7. Comparison of Hypothalamus-Pituitary-Adrenal Axis Suppression From Superpotent Topical Steroids by Standard Endocrine Function Testing and Gas Chromatographic Mass Spectrometry [O] . Weston William L., Fennessey Paul V., Morelli Joseph., 1988

机译：标准内分泌功能测试和气相色谱质谱法比较超强局部类固醇下丘脑-垂体-肾上腺轴的抑制作用
8. Financial Regulatory Reform: Systemic Risk and the Federal Reserve. Updated May 26, 2010 [R] . Labonte, M. 2010

机译：金融监管改革：系统性风险与美联储。 2010年5月26日更新

Update on the Systemic Risks of Superpotent Topical Steroids

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