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首页> 外文期刊>Journal of drugs in dermatology: JDD >The Effect of Isotretinoin on Vitiligo and Autoimmune Comorbidity
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The Effect of Isotretinoin on Vitiligo and Autoimmune Comorbidity

机译：异黄基对白癜风和自身免疫合并症的影响

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摘要

Several case reports have noted development of vitiligo as a potential side-effect of isotretinoin. In an IRB approved on-line survey of vitiligo patients we queried 1,301 vitiligo patients, 1115 with generalized vitiligo responding as to whether they had taken isotretinoin to address whether this issue was a common phenomenon amongst vitiligo patients. 3.6% of respondents had taken isotretinoin, 1.4% (n=16) before onset of vitiligo, and 2.2% (n=24) after onset of vitiligo. When compared with age-matched vitiligo peers who had not taken isotretinoin before onset of vitiligo (n=64), isotretinoin use prior to onset of vitiligo was associated with: decreased disease body surface area (conditional logistic regression: OR of BSA50 /0 (95% CI)=0.12 (0.03-0.57), P=0.007); decreased odds of body and face involvement when compared with either body or face alone (OR (95% CI)=0.20 (0.06-0.73), P=0.02); and decreased co-morbid autoimmunity (OR (95% 0)=0.17 (0.04-0.58), P=0.01). The volume of isotretinoin usage in vitiligo patients is additionally suggestive of a link between cystic acne and vitiligo.
机译：有几个案例报告已经注意到白癜风的发展，作为异马托萘苷的潜在副作用。在IRB批准的白癜风患者的在线调查我们询问1,301名白癜风患者，1115患者与广义白癜风响应他们是否已经服用异黄素，以解决这个问题是否是白癜风患者的常见现象。 3.6％的受访者已经在白癜风发作前服用二丙替替亚丁，1.4％（n = 16），比白癜风发作后2.2％（n = 24）。与未在白癜风（n = 64）开始前没有服用异黄素的白癜风同伴相比，白癜风发作前的异丙替税素使用与：疾病体表面积减少（条件逻辑回归：或BSA50 / 0（ 95％CI）= 0.12（0.03-0.57），P = 0.007）;与单独的身体或面部相比（或（95％CI）= 0.20（0.06-0.73），p = 0.02）相比，身体的几率和面部受累并降低副病态自身免疫（或（95％0）= 0.17（0.04-0.58），p = 0.01）。白癜风患者的异丙键使用量涉及囊性痤疮和白癜风之间的联系。

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