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首页> 外文期刊>Journal of Dispersion Science and Technology >Surface properties and doxorubicin delivery in mixed systems comprising a natural rosin-based ester tertiary amine and an anionic surfactant
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Surface properties and doxorubicin delivery in mixed systems comprising a natural rosin-based ester tertiary amine and an anionic surfactant

机译：在混合体系中的表面性质和多柔比星输送，其包含天然松香基酯三胺和阴离子表面活性剂

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摘要

A rosin-based ester tertiary amine salt (RETAS) cationic surfactant was obtained using natural rosin as raw material. GC-MS of RETAS was detailed analyzed. The pH-responsive mechanism of rosin-based ester tertiary amine (RETA) and RETAS was confirmed by applying theoretical calculations about electrostatic potential maps of RETA and RETAS cation using Gaussian software. Mixed system surfactants were obtained by blending RETAS cationic surfactant with sodium dodecyl benzene sulfonate (SDBS) anionic surfactant. The binary mixed surfactant systems of RETAS and SDBS had obvious synergistic effect. The gamma(cmc) and CMC were 39.40 mN/m and 0.56 mmol/L at the optimum molar fraction of RETAS (alpha) = 0.6, respectively. The stability time of emulsion with the optimum mixed system as emulsifier increased to 309 s at alpha = 0.6. The emulsifying capacity of RETAS was much better than that of RETA. RETAS had pH-responsive targeted release and the optimum mixed system showed a relatively sustained drug release by using doxorubicin (DOX) as a model drug. These results indicate that RETAS surfactant and mixed system surfactant are both promising for applications in drug delivery and emulsification.
机译：使用天然松香作为原料获得松香基酯叔胺盐（RetAs）阳离子表面活性剂。详细分析了RetA的GC-MS。通过使用高斯软件应用关于RETA的静电潜在地图的理论计算来确认松香基酯叔胺（RETA）和RETA的pH-响应机制。通过将Retas阳离子表面活性剂与十二烷基苯磺酸钠（SDB）阴离子表面活性剂混合来获得混合系统表面活性剂。转乳和SDB的二元混合表面活性剂系统具有明显的协同效应。 γ（CMC）和CMC分别为39.40mN / m和0.56mmol / L，分别为0.5的最佳摩尔分数（α）= 0.6。作为乳化剂在α= 0.6的乳化剂增加到309秒的乳液的乳液的稳定性时间。 RetA的乳化容量远远优于Reta。 Retas具有pH-响应靶向释放，并且最佳混合系统通过使用多柔比星（DOX）作为模型药物显示出相对持续的药物释放。这些结果表明，RETAS表面活性剂和混合体系表面活性剂在药物递送和乳化方面都有希望。

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  • 作者

    Tian Chao; Liang Yuanli; Lin Haixia; Song Jie; Li Qi; Li Rui; Han Chunrui;

  • 作者单位

    Beijing Forestry Univ Coll Mat Sci &

    Technol MOE Engn Res Ctr Forestry Biomass Mat &

    Bioenergy Beijing Key Lab Lignocellulose Chem Beijing Peoples R China;

    Beijing Forestry Univ Coll Mat Sci &

    Technol MOE Engn Res Ctr Forestry Biomass Mat &

    Bioenergy Beijing Key Lab Lignocellulose Chem Beijing Peoples R China;

    Beijing Forestry Univ Coll Mat Sci &

    Technol MOE Engn Res Ctr Forestry Biomass Mat &

    Bioenergy Beijing Key Lab Lignocellulose Chem Beijing Peoples R China;

    Univ Michigan Dept Chem &

    Biochem Flint MI 48503 USA;

    Youcare Pharmaceut Grp Co Ltd Beijing Peoples R China;

    Beijing Forestry Univ Coll Mat Sci &

    Technol MOE Engn Res Ctr Forestry Biomass Mat &

    Bioenergy Beijing Key Lab Lignocellulose Chem Beijing Peoples R China;

    Beijing Forestry Univ Coll Mat Sci &

    Technol MOE Engn Res Ctr Forestry Biomass Mat &

    Bioenergy Beijing Key Lab Lignocellulose Chem Beijing Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 胶体化学（分散体系的物理化学）;
  • 关键词

    Rosin-based; tertiary amine; mixed system; emulsification; drug-delivery;

    机译：基于松香的;叔胺;混合系统;乳化;药物交付;

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