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首页> 外文期刊>Journal of drug delivery science and technology >Thymoquinone loaded dermal lipid nano particles: Box Behnken design optimization to preclinical psoriasis assessment
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Thymoquinone loaded dermal lipid nano particles: Box Behnken design optimization to preclinical psoriasis assessment

机译：胸腺喹诺酮负载皮肤脂纳米颗粒：盒BEHNKEN设计优化，临床前牛皮癣评估

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The present study was to formulate and optimize Thymoquinone (TQ) lipid nanoparticles (NPs) formulations for the treatment of psoriasis. The formulation optimization was performed using the independent variables [(ge-lucire (A), capmul (B), sonication time(C)] at three levels (low, medium and high) and their individual and combined effects were assessed on size (Z_1), poly dispersity index (Z_2) and drug encapsulation (Z_3). The results of the present study revealed that the point prediction based TQNPopt showed low particle size (84.22 ± 3.31 nm), PDI (0.26 ± 0.02) and high entrapment efficiency (81.3 ± 4.11%). The drug release and dermal permeation result showed slow drug release (57.55 ± 5.38%) and enhanced dermal flux (5.77 mug/cm~2/ h). The TEM image and thermal analysis revealed sealed, spherical shape particle and the disappearance of the characteristic endothermic peak of TQ. The skin irritation study score revealed the primary irritation index score (1.4) and further PASI score confirmed the reduction in all the parameters (erythema, edema, and thickening) in psoriatic model in compare to the toxic control group. The present study data revealed that the developed lipid nano particles formulation was found to be a potentially useful dermal carrier for TQ.
机译：本研究是制备和优化脂醌（TQ）脂质纳米颗粒（NPS）制剂用于治疗牛皮癣。使用独立变量进行配方优化[（Ge-Lucire（A），Capmul（B），超声时间（c）]，在三个级别（低，中等和高）以及它们的个体和组合效果进行大小（ Z_1），聚分层指数（Z_2）和药物包封（Z_3）。本研究结果表明，基于点预测的TQNPOPT显示出低粒径（84.22±3.31nm），PDI（0.26±0.02）和高血管效率（81.3±4.11％）。药物释放和皮肤渗透结果表现出慢的药物释放（57.55±5.38％）和增强的皮肤助焊剂（5.77 mug / cm〜2 / h）。TEM图像和热分析显示出密封的球形形状粒子和TQ的特征吸热峰的消失。皮肤刺激性研究得分揭示了初级刺激指数评分（1.4），进一步的PASI评分证实了在比较中的银屑病模型中的所有参数（红斑，水肿和增稠）的减少毒性控制p。本研究数据显示，发现发发的脂质纳米颗粒制剂是TQ的潜在有用的皮肤载体。

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