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首页> 外文期刊>Journal of drug delivery science and technology >Formulation and evaluation of fluconazole loaded oral strips for local treatment of oral candidiasis
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Formulation and evaluation of fluconazole loaded oral strips for local treatment of oral candidiasis

机译：氟康唑载有口服条带的制剂和评价，用于口腔念珠菌病的局部治疗

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This study aimed to develop fluconazole loaded buccal mucoadhesive oral strip for local treatment of oral candidiasis. Oral strip was prepared by solvent casting method with different polymer combinations and evaluated for weight, thickness, drug content, tensile strength, swelling behavior, in vitro disintegration time and drug release, ex vivo mucoadhesive performance, stability study, ex vivo drug diffusion and in vitro antifungal activity. Oral strips were smooth and elegant in appearance; were uniform in thickness, weight and drug content. The disintegration time was within the range of 23-28 s. The release rates of fluconazole from oral strips reached approximate to 96%. The optimum formulation was stable for 6 months. The in vitro antifungal activity studies showed the efficacy of the oral strip against Candida albicans for an extended period. Cytotoxicity was also studied, and no cytotoxic effect was observed at the tested concentration. The developed oral strip can be a promising delivery system in oral candidiasis.
机译：本研究旨在开发氟康唑载有颊粘膜粘附性口腔，用于局部治疗口腔念珠菌病。口腔带材由溶剂铸造方法制备，具有不同的聚合物组合，并评估重量，厚度，药物含量，拉伸强度，肿胀行为，体外崩解时间和药物释放，稳定性研究，离体内药物扩散和稳定性体外抗真菌活性。口腔条在外观光滑而优雅;厚度，重量和药物含量均匀。崩解时间在23-28秒的范围内。口服条带的氟康唑的释放速率达到近似为96％。最佳制剂稳定6个月。体外抗真菌活性研究表明，口腔带对念珠菌的效果延长了念珠菌。还研究了细胞毒性，并且在测试浓度下没有观察到细胞毒性效应。发达的口腔带子可以是口腔念珠菌病中有前途的递送系统。

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