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首页> 外文期刊>Journal of drug delivery science and technology >Efficiency of nanoparticles for treatment of ocular infections: Systematic literature review
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Efficiency of nanoparticles for treatment of ocular infections: Systematic literature review

机译：用于治疗眼部感染的纳米粒子的效率：系统文献综述

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摘要

Eye infections are growing medical problems in recent years, and conjunctivitis and keratitis are the most important eye infections, which are generally treated with conventional drugs. However, the old drug delivery system has failed to combat the disease due to poor ocular bioavailability, low ocular residence time, high rate of antibiotic resistance and some allergic reactions. Therefore, finding efficient drug delivery system for ophthalmic drug delivery such as using lipid and polymeric nanoparticles (NPs) are currently the matter of interest. In this study, we systematically review all available literatures that investigated the application of NPs as delivery system or as anti-infective agent in ophthalmic infections. For this purpose, a systematic literature search was performed in PubMed, Scopus, Embase, Web of Science, Medline, Ovid, Science Direct, and Google Scholar by using eye infections and NPs and all their equivalent terms as keyword. Since no clinical trials have been performed on this subject, all in vivo studies were included. Of the total of 442 documents, only 29 articles completely met the inclusion criteria and used for data synthesis. The results showed that using NPs and nanocarriers for this purpose can be a promising approach due to their high corneal penetration, bioavailability and ocular residence time that can lead to better compliance of patients. Based on the findings of the included studies, it is suggested that NPs and nanocarriers can be an effective and potential alternative for conventional drug delivery systems; however, further clinical trials are necessary to confirm such efficiency in clinical practice.
机译：近年来眼睛感染越来越大，结膜炎和角膜炎是最重要的眼部感染，通常用常规药物治疗。然而，由于眼部生物利用度差，低眼部停留时间，抗生素抗性高和一些过敏反应，旧药物递送系统未能打击疾病。因此，寻找用于眼科药物递送的有效药物递送系统，例如使用脂质和聚合物纳米颗粒（NPS）是目前感兴趣的问题。在这项研究中，我们系统地审查所有可用的文献，调查了NPS作为递送系统的应用或作为眼科感染中的抗感染剂。为此目的，通过使用眼睛感染和NPS以及关键字的所有等效条款，在PubMed，Scopus，Embase，Science和Google Scholar中进行系统文献搜索。由于没有对该受试者进行临床试验，因此包括所有体内研究。其中442份文件中，只有29篇文章完全符合纳入标准并用于数据综合。结果表明，由于它们的高角膜穿透，生物利用度和眼部停留时间，使用NPS和纳米载波可能是一种有希望的方法，可以导致患者更好地遵守患者。基于所附研究的发现，建议NPS和纳米载波可以是常规药物递送系统的有效和潜在的替代品;然而，需要进一步的临床试验来确认临床实践中的效率。

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