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Bacterial cytoskeleton and implications for new antibiotic targets

机译:细菌细胞骨架和新抗生素靶标的影响

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摘要

Traditionally eukaryotes exclusive cytoskeleton has been found in bacteria and other prokaryotes. FtsZ, MreB and CreS are bacterial counterpart of eukaryotic tubulin, actin filaments and intermediate filaments, respectively. FtsZ can assemble to a Z-ring at the cell division site, regulate bacterial cell division; MreB can form helical structure, and involve in maintaining cell shape, regulating chromosome segregation; CreS, found in Caulobacter crescentus (C. crescentus), can form curve or helical filaments in intracellular membrane. CreS is crucial for cell morphology maintenance. There are also some prokaryotic unique cytoskeleton components playing crucial roles in cell division, chromosome segregation and cell morphology. The cytoskeleton components of Mycobacterium tuberculosis (M. tuberculosis), together with their dynamics during exposure to antibiotics are summarized in this article to provide insights into the unique organization of this formidable pathogen and druggable targets for new antibiotics.
机译:传统上,真核生物专属细胞骨架已发现在细菌和其他原核生物中。 FTSZ,MREB和CRES分别是真核细胞蛋白,肌动蛋白细丝和中间细丝的细菌对应。 FTSZ可以组装在细胞分裂部位的Z形环,调节细菌细胞分裂; MREB可以形成螺旋结构,并涉及保持细胞形状,调节染色体隔离; Cres,发现在Carobacter Crescentus(C. crescentus)中,可以在细胞内膜中形成曲线或螺旋细丝。 Cres对细胞形态维护至关重要。还有一些原核独特的细胞骨架组分在细胞分裂,染色体隔离和细胞形态中起着至关重要的作用。本文总结了在暴露于抗生素期间,结核分枝杆菌(Cuberculosis)的细胞骨架组分及其动力学,并提供进入新抗生素的这种强制性病原体和可用性靶标的独特组织的见解。

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