...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of drug targeting >Collagen nanofiber containing silver nanoparticles for improved wound-healing applications
【24h】

Collagen nanofiber containing silver nanoparticles for improved wound-healing applications

机译：含银纳米粒子的胶原纳米粒子用于改善伤口愈合应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Electrospun nanofibers showing great promise for fabricating nanostructured materials might help to improve the quality of wound care. The present study aimed to investigate the wound-healing potential of collagen nanofiber mats containing silver nanoparticles. Silver nanoparticles (AgNPs) synthesized by the chemical reduction method were incorporated in collagen nanofibers during the electrospinning process. Characterization of electrospun nanofiber mats revealed a mean fiber diameters in the range of 300-700 nm with a sustained release of silver ions shown to follow pseudo-order kinetics. MIC of AgNPs against Staphylococcus aureus and Pseudomonas aeruginosa were evaluated using micro-dilution assay and further antimicrobial activity of fabricated nanofibers was performed. Finally, in vivo studies were performed to demonstrate the wound-healing efficacy of composite nanofibers. In vitro results confirmed the potential antimicrobial efficacy provided by AgNPs and AgNPs composite nanofibers, essential to provide an aseptic environment at the wound site. In vivo study revealed that the rate of wound healing of the composite nanofiber mats was found to be accelerated compared with plain collagen nanofibers. Histology analysis revealed an accelerated re-epithelization, collagen production, and better wound contraction with AgNPs composite collagen nanofibers.
机译：Electrom X纳米纤维显示纳米结构材料的巨大希望可能有助于提高伤口护理的质量。本研究旨在研究含有银纳米粒子的胶原纳米纤维垫的伤口愈合潜力。通过化学还原法合成的银纳米颗粒（AgNP）在静电纺丝过程中掺入胶原纳米纤维中。电纺纳米纤维垫的表征显示300-700nm范围内的平均纤维直径，持续释放银离子，如伪阶动力学遵循伪序动力学。使用微量稀释测定评价对金黄色葡萄球菌和假单胞菌铜绿假单胞菌的突发孔，并进行制造纳米纤维的进一步抗微生物活性。最后，在体内研究中进行了表明复合纳米纤维的伤口愈合效果。体外结果证实了AgNP和AgNPS复合纳米纤维提供的潜在抗微生物功效，其在伤口部位提供无菌环境。在体内研究表明，与平原胶原型纳米纤维相比，发现复合纳米纤维垫的伤口愈合速率加速。组织学分析揭示了加速的再上皮，胶原蛋白生产和与AgNPS复合胶原蛋白纳米纤维的更好的伤口收缩。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号