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首页> 外文期刊>Journal of drug targeting >Systematically optimized coenzyme q10-loaded novel proniosomal formulation for treatment of photo-induced aging in mice: characterization, biocompatibility studies, biochemical estimations and anti-aging evaluation
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Systematically optimized coenzyme q10-loaded novel proniosomal formulation for treatment of photo-induced aging in mice: characterization, biocompatibility studies, biochemical estimations and anti-aging evaluation

机译：系统地优化辅酶Q10加载的新药调位制剂，用于治疗小鼠的光诱导老化：表征，生物相容性研究，生物化学估计和抗衰老评价

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摘要

Environmental stress and advancing age is considered as the main cause of skin aging. However, environmental stress (especially UV radiations) accelerates the process of skin aging by manifolds. Coenzyme Q10 (CoQ(10)), an essential compound of cellular bioenergetics also acts as a strong antioxidant and protects the body against aging. High molecular weight and structure specific lipophilic nature of this molecule is a bottle neck in effective delivery through topical route. Preparation of a novel proniosomal (PN) gel formulation of CoQ(10) employing systematic design of experiment (DoE) approach is a step ahead in transcending the constraints of the topical delivery. I-optimal mixture design was employed for systematic optimization of proniosomal formulation and evaluation of experimental data was performed for entrapment efficiency and in vitro release. Hydration of PN gel formulation with phosphate buffer (pH 7.5) results in submicron niosomes vesicles of spherical shape, which appeared dark against bright surroundings in TEM study. Animal skin was treated with UV radiations followed by treatment of PN gel CoQ(10) and conventional CoQ(10) present in a gel base. The effectiveness of the treatment was evaluated on the basis of biochemical estimation and histopathological studies. By using CoQ(10) PN gel formulation, levels of superoxide dismutase (SOD), catalase (CA), glutathione (GSH) and total proteins were restored by 81.3%, 72.1%, 74.8 and 77.1%, respectively to that of control group. Histopathological studies revealed better protection of skin treated with CoQ(10) PN gel compared to free CoQ(10). Prepared PN gel was found undisturbing with the normal histology hence, tolerated by animal skin compare to conventional gel.
机译：环境压力和推进年龄被视为皮肤老化的主要原因。然而，环境压力（特别是紫外线辐射）通过歧管加速皮肤老化的过程。辅酶Q10（CoQ（10）），细胞生物终端学的基本化合物也充当强烈的抗氧化剂并保护身体免于衰老。该分子的高分子量和结构特异性亲脂性性质是通过局部途径有效递送的瓶颈。制备一种新的强制性（PN）凝胶制剂的CoQ（10）采用的实验系统设计（DOE）方法是超越局部交付的限制的前进。 I-最佳混合设计用于治疗调发术语制剂的优化，对熵效率和体外释放进行实验数据的评估。用磷酸盐缓冲液（pH7.5）的PN凝胶制剂的水合结果导致亚微米的球形囊泡的球形形状囊泡，其在TEM研究中出现黑暗的环境。用UV辐射治疗动物皮肤，然后处理凝胶碱中存在的PN凝胶COQ（10）和常规的CAQ（10）。根据生物化学估计和组织病理学研究评估治疗的有效性。通过使用CAQ（10）PN凝胶制剂，通过81.3％，72.1％，74.8％和77.1％，恢复超氧化物歧化酶（SOD），谷胱甘肽（CA），谷胱甘肽（GSH），谷胱甘肽（GSH）和总蛋白质的水平分别恢复到对照组的81.3％，72.1％，77.1％ 。组织病理学研究表明，与游离COQ（10）相比，通过CAQ（10）PN凝胶处理的皮肤更好地保护皮肤。发现制备的PN凝胶与正常的组织学不受干扰，因此通过动物皮肤与常规凝胶相比耐受。

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